Does Indoxyl Sulfate Have a Role in Uremic Pruritus? A Laboratory and Interventional Study.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 45
- 试验地点
- 2
- 主要终点
- Severity of itching
研究概览
简要总结
Itching is a widespread and disturbing complain from patients with chronic kidney disease (CKD); epidemiologic data have suggested that approximately 40% of patients with end-stage renal disease experience moderate to severe itching. The pathogenesis of renal pruritus is multifactorial. Triggering factors may include uremia-related abnormalities, accumulation of uremic toxins, systemic inflammation and cutaneous xerosis. Indoxyl sulfate (IS) is a protein-bound uremic toxin resulting from the metabolism of dietary tryptophan accumulating in patients with end-stage renal disease.
详细描述
Patients with end-stage renal disease undergoing hemodialysis complaining of itching not related to other cause than renal failure will take activated charcoal with foods and serum level of indoxyl sulphate will be studied
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients with end-stage renal failure with itching undergoing regular hemodialysis
排除标准
- •Patients with other causes of itching as psoriasis, atopic dermatitis, scabies, and lichen planus
研究组 & 干预措施
Uremic Pateints group
Patients with end-stage renal failure with itching
干预措施: Uremic pateints with itching (Dietary Supplement)
结局指标
主要结局
Severity of itching
时间窗: Two months
Change of severity of itching by The Visual Analogue Scale score
次要结局
未报告次要终点
研究者
Essam Mohamed El-sayed Akl
Assistant Professor of Dermatology and Andrology
Benha University