Metabolic and Structural Characterization of Hub's Vulnerability in Neurological Diseases Assessed by Ultra High Field Structural and Functional MRI
试验速览
- 阶段
- 不适用
- 入组人数
- 260
- 试验地点
- 2
- 主要终点
- Index of reorganization of the structural hubs (ks-Degree)
研究概览
简要总结
the investigators hypothesize that hub alteration occurs both in diffuse diseases (MS, AD) as well as in more 'network specific' diseases (Parkinson, ALS, Epilepsy). This could impact on functional dysfunction not directly related to each disease, but that could induce common syndrome such as cognitive impairment observed in Parkinson, partial epilepsy or ALS.
The objective here is to test this hypothesis and provides better understandings on pathophysiological processes affecting those highly connected regions in 'diffuse' and 'focal' neurological diseases.
The ultimate goal is to identify new clinical targets for trans-nosological approaches (DBS, cognitive rehabilitation ...).
Practically, the investigators will explore 200 patients classified in 5 cohorts of 40 patients suffering for MS, AD, Parkinson, ALS, Epilepsy, using the last advanced methods to assess structural and functional brain connectivity implemented on the human 7T MR scanner equipping the CEMEREM (CHU Timone, Marseille, only 50 similar MR scanners worldwide).
In addition to high resolution diffusion MRI and rs-fMRI, metabolic and ionic (sodium) mapping will complement the MR protocol to characterize the pathophysiological processes of hub injury. Sixty healthy controls will also be explored wih the same protocol for normal database.
The proposal aims at characterizing and comparing from a morphological-functional point of view, the hub regions of patients suffering from these five diseases, to demonstrate the pertinence to preserve hub integrity as a major therapeutic target whatever the disease.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Person female or male, more than 18-year-old,
- •Person presenting unchecked general disease such as severe cancer, autoimmune disease, hepatic insufficiency, severe or untreated, shady arterial high blood pressure of the conduction or the disorder of the rhythm
- •Person presenting chronic psychiatric disease, insane syndrome.
- •Person presenting contraindication to the realization of an examination by MRI (metallic claustrophobia, foreign body, pacemakers),
- •Person benefiting from a social security cover,
- •Person having read, understood and signed an informed consent after information
排除标准
- •Claustrophobia,
- •Metallic foreign bodies,
- •Pacemakers,
- •Severe renal insufficiency
结局指标
主要结局
Index of reorganization of the structural hubs (ks-Degree)
时间窗: 5years
次要结局
- Concentrations of sodium within hubs(5 years)
- Concentrations of Glutamate/Glutamine within hubs(5 years)
- Iron accumulation within hubs(5 years)
- cortical Thicknesses within hubs(5 years)