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临床试验/ISRCTN80857707
ISRCTN80857707已完成不适用

The effect of omega-3 polyunsaturated fatty acid dose level on hyperpnoea-induced bronchoconstriction and markers of airway inflammation in asthma

ottingham Trent University (UK)0 个研究点目标入组 108 人开始时间: 2016年5月13日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
108

研究概览

研究设计

研究类型
Interventional

入排标准

性别
Male

入选标准

  • 1. Body mass index (BMI) 20-25 kg.m-2
  • 2. Physically active 3 or more times a week , with each exercise session lasting at least 45 min
  • 3. Non-smoker
  • 4. Non-vegetarian or vegan
  • 5. Asthma sufferers must have own clinically prescribed medication
  • 6. Asthma sufferers must have a GP diagnosis

排除标准

  • 1. Predicted forced expiratory volume in 1 second (FEV1) less than 65%
  • 2. Previously diagnosed with COPD, emphysema, chronic bronchitis or similar respiratory illness
  • 3. Previously admitted to hospital for asthma or other breathing difficulties
  • 4. Asthma exacerbation within the last month (course of steroids or hospital visit)
  • 5. History of heart failure, pulmonary hypertension, embolism, or other pulmonary heart disease
  • 6. History of recurrent chest infections
  • 8. Acute infection within the last four weeks
  • 9. Major operation within the past four months
  • 10. Have a history of taking ?-3 PUFA supplements or supplements with antioxidants above recommended intake, or consume more than three fatty fish meals per week
  • 11. Take a daily dose of aspirin or other NSAIDs
  • 12. Currently taking a daily dose of anti-histamine
  • 13. Currently taking long-term asthma maintenance medications – corticosteroids, and leukotriene modifiers that you could not refrain from taking for 4 days prior to laboratory session

研究者

发起方
ottingham Trent University (UK)

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