Chronic Kidney Disease in the Pakistani Population
试验速览
- 阶段
- 不适用
- 入组人数
- 650
- 试验地点
- 1
- 主要终点
- GFR will be measured as the mean of at least two urinary clearance periods of Inulin
研究概览
简要总结
The Indo-Asian developing countries are facing an epidemic of chronic diseases including hypertension, diabetes and chronic kidney disease (CKD). Diagnosis of early CKD is essential for institution of effective and timely prevention of its complications; costly late stage treatment for end stage renal disease is currently an unfeasible option in these populations. GFR estimates of kidney function provide a common reference standard for all people and are therefore readily applicable by physicians and understood by patients. However, the existing GFR equations yield widely discrepant results in the Indo Asian population, and none of the currently available estimating equations have been validated in this population.
The main objective is to develop a tool which can be used for screening subjects at high risk for developing CKD (with hypertension and diabetes) as well as the general population.
详细描述
The proposed study is being conducted at the Aga Khan University in collaboration with Tufts-New England Medical Center and Imperial College, UK. It is a population based cross-sectional study using a 2-stage cluster design. The study would be performed on 650 adult subjects from the general population in Karachi.
A new GFR equation specific to a Pakistani population would be developed and validated using the gold standard of measured Insulin GFR. The performance of the new equation will be compared to the existing ones developed in other populations with respect to bias, precision, and accuracy.
The project is likely to contribute significantly to moving the field to kidney disease forward, and its results are likely to have far reaching implications for understanding of CKD and, ultimately, its prevention in Indo-Pakistani populations worldwide.
研究设计
- 研究类型
- Observational
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 40 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All individuals aged 40 years and above
排除标准
- •Shortness of breath on minimal to moderate exertion
- •Acute fibril illness
- •Doctor diagnosed liver disease
- •Doctor diagnosed rheumatological disease
- •Heart attack within past three months
- •Pregnancy
- •Mentally incompetent to give informed consent
- •Too frail to travel to clinic
- •Bed ridden subjects
结局指标
主要结局
GFR will be measured as the mean of at least two urinary clearance periods of Inulin
次要结局
未报告次要终点