Memantine Augmentation of Electroconvulsive Therapy in Patients With Major Depression
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 发起方
- 试验地点
- 1
- 主要终点
- Assessment of whether Memantine protects memory and cognitive impairment caused by ECT.
研究概览
简要总结
The purpose of this study is to determine whether memantine will enhance the therapeutic of effect on depression and prevent memory and other cognitive problems caused by ECT.
详细描述
Patients will be assigned randomly either to a treatment group or a placebo groups. All patients in both groups will be receiving standard ECT. The treatment group will receive memantine. All patients will be given a battery of cognitive tests and test of depression before ECT treatments start, after the 6th ECT treatment and after the completions of ECT. An analysis will be performed to see if memantine causes any impact on the response to ECT and prevents memory and cognitive impairment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Meets criteria for Major Depressive disorder
排除标准
- •Neurological disease
- •Mental retardation
- •Seizure disorder
研究组 & 干预措施
Memantine arm
Patient receiving ECT and Memantine
干预措施: memantine (Drug)
placebo
25 patients receiving ECT will will receive placebo
干预措施: memantine (Drug)
placebo
25 patients receiving ECT will will receive placebo
干预措施: Placebo (Drug)
结局指标
主要结局
Assessment of whether Memantine protects memory and cognitive impairment caused by ECT.
时间窗: 6 to 8 weeks
次要结局
- Whether memantine will improve response of Depression to Electroconvulsive therapy.(6-8 weeks)
研究者
Jerrry L Lewis
Principal Investigator
University of Iowa