A Randomized Crossover Trial to Compare the Changes of Postprandial Oxidative Stress After Consumption of Meals From Different Cultures in Healthy Chinese Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 33
- 试验地点
- 1
- 主要终点
- Change of plasma allantoin from 0 (pre-meal) to 6 hours post-meal
研究概览
简要总结
This one-year randomized crossover study is proposed to compare the changes of postprandial oxidative stress (POS) after consumption of meals from different cultures in healthy Chinese adults, using a 'real-life, cultural meal' approach. It is hypothesized that the changes of POS differ with meals from different cultures. Four cultural meals are chosen, namely Southern Chinese, Northern Chinese, American, and South Indian, based on the known prevalence of chronic diseases between Caucasians, Chinese and Indians, and within the Southern and Northern Chinese population.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Apparently healthy male or female of Chinese ethnicity with BMI less than 25 kg/m2
- •Aged from 18 to 45 years for female to avoid menopausal effect, and 18 to 50 years for male (inclusive)
- •Normal glucose tolerance as assessed by fasting HbA1c of <6% at the screening
- •Willing to give consent and follow the study procedures
排除标准
- •Lifestyle factors that affect POS as shown by the literature including
- •Current smoker
- •Physically active as defined by three days or more of 30 minutes [accumulated over the course of a day] moderate to vigorous activity weekly in the past three months. Vigorous physical activity is described as causing heavy sweating or a large increase in breathing or heart rate, and moderate as causing light sweating or a slight to moderate increase in breathing or heart rate.
- •Regular or current use of vitamin or antioxidant supplements
- •Pregnant or lactating
- •Concurrent participation in any clinical trial or dietary intervention program
- •Adherence to a special diet, allergies or aversions to foods on the study meals
- •Use of medications that could affect study outcomes
- •With diabetes, hypertension, renal, liver or thyroid dysfunction, any other indication of a major medical or psychological illness, as judged by the investigators as ineligible to participate the study
结局指标
主要结局
Change of plasma allantoin from 0 (pre-meal) to 6 hours post-meal
时间窗: pre-meal (0 hour), 2, 4, 6 hours post-meal
次要结局
- Change of urine F2-isoprostanes from 0 (pre-meal) to 6 hours post-meal(pre-meal (0 hour), 2, 4, 6 hours post-meal)
研究者
Ruth Chan
Research assistant professor
Chinese University of Hong Kong