Impact of a Public Commitment Charter Associated With Patient Information Leaflets on Antibiotics Prescribed by General Practitioners
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 349
- 试验地点
- 2
- 主要终点
- Impact of a public commitment charter associated with patient information leaflets on antibiotic's prescription
研究概览
简要总结
This study is a pragmatic, randomised, controlled, before-after interventional study conducted in one region in France in primary care. The GPs in the intervention group will receive a public commitment charter, a non prescription pad and a patient information leaflet to be used when antibiotics are prescribed, while the control group will be not aware of the intervention.
详细描述
Antimicrobial resistance is a major public health threat and the overuse of antibiotics contributes to its development.
In France, outpatient antibiotic use remains above the European average. Ninety percent of antibiotics are prescribed to outpatients and 70% of these are prescribed by general practitioners.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •working in the Lorraine region in France
- •prescribing more than 25 antibiotic items per 100 patients without a chronic illness, aged 16 to 65 years
- •proportion of patients treated with critical antibiotics exceeding 27% (among patients treated with antibiotics)
排除标准
- •practicing exclusively alternative medicine, such as homeopathy or acupuncture
- •GPs reaching the retirement age in the two years following the beginning of the intervention or who were not working two years before
- •GPs who had already displayed a commitment charter promoting antibiotic stewardship in their practice
结局指标
主要结局
Impact of a public commitment charter associated with patient information leaflets on antibiotic's prescription
时间窗: 2 years
prescription rate by all included GPs of all systemic antibiotics (J01 code according to the Anatomical Therapeutic Chemical - ATC - 2017 classification) between the "before" (2017-2018) and "after" (2018-2019) period using an auto regressive integrated moving average (ARIMA) model
次要结局
- Adherence of GPs regarding the intervention: display of the public commitment charter(1 years)
- Adherence of GPs regarding the intervention: use patient information leaflets(1 years)
- Impact of the intervention on the seasonal variation of both total antibiotic use and quinolones' use(2 years)
- Impact of the public commitment charter associated with patient information leaflets on broad-spectrum antibiotics' prescriptions(2 years)
- Acceptability of the intervention by GPs(1 years)