NCT00340392已完成不适用
Isolation and Characterization of Mammary Stem Cells
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 400
- 试验地点
- 1
研究概览
简要总结
Background:
- Cancer stem cells in breast cancer have been identified as a small population of tumor cells whose self-renewal mechanism is highly deregulated. This deregulation seems to be necessary for cancer to develop.
- These cells can be identified by certain surface markers that overlap with markers associated with normal embryonic stem cells.
Objective: To isolate tumor stem cells using the same methods generally used to isolate human embryonic stem cells.
Eligibility:
- Tissue samples will be obtained from the human cooperative network.
- Samples will include normal tissues from individuals who have no opportunistic diseases and from individuals with cancer.
Design: Breast cancer stem cells will be isolated, grown in the laboratory and characterized.
详细描述
Cancers are composed of heterogeneous populations of cells with varying degrees of proliferative capacity and ability to reconstitute tumors when transplanted into nude or SCID mice.
Recently, cancer stem cells have been identified as a small population of tumor cells which possess the stem cell properties in that their self-renewal pathway is highly deregulated. This deregulation seems to be the prerequisite for the development of cancer.
研究设计
- 研究类型
- Observational
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
研究者
研究点 (1)
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