Aspiration thrombectomy versus combining aspiration with stent retriever in Stroke Patients for Improved Reperfusion Efficiency Trial - ASPIRE

Toyoda Kazunori0 个研究点目标入组 40 人开始时间: 2022年1月22日最近更新: 2023年10月17日

试验速览

暂无简介。

•1) Aged 20 years or older
•2) Hospital arrival within 24 hours of onset
•3) Acute ischemic stroke
•4) No disability prior to the index stroke (modified Rankin Scale 0-2)
•5) NIH Stroke Scale score of 6 or higher
•6) Occlusion of the interal carotid artery or M1 segment of the middle cerebral artery on CT or MRI at presentation
•7) ASPECTS of 6 or higher
•8) Written informed consent from the patient or from a relative

•1) Occlusion of the extracranal internal carotid artery
•2) Blood glucose level 50 mg/dL or lower when obtaining consent
•3) Allergy to iodinated contrast agents
•4) Intracranial hemorrhage on CT/MRI
•5) Severe intracranial space occypying effects with midline shift on CT/MRI
•6) Clinical evidence of chronic occlusion
•7) Multiple occlusions of cerebral arteries
•8) Pregnancy of suspected pregnancy
•9) Participation in other clinical trials
•10) An estimated life expectancy of less than 12 months due to causes other than acute ischemic stroke
•11) Severe allergy or hypersensitivity to nickel-titanium alloy, nickel-chromium, platinum-tungsten alloy, or stainless steel
•12) Patients with highly tortuous vessels that make it difficult to deliver devices to the target vessel
•13) Carotid artery dissection, occlusion of the entire cervical carotid artery, or vasculitis
•14) Uncontrollable hypertension (systolic blood pressure of 185 mmHg or higher or diastolic blood pressure of 110 mmHg or higher)
•15) Intracranial tumors (except for small meningiomas)
•16) Patients on anticoagulant therapy with a PT-INR >3 or an activated partial thromboplastin time >2 times the normal value
•17) A platelet count of less than 50,000/micro-L
•18) Unable to obtain consent for mechanical thrombectomy as clinical practice
•19) Patients who are judged inappropriate for participation in the study by the investigators for any other reason

发起方

Toyoda Kazunori