NCT02933606已完成2 期
A Randomized, Double-blind, Placebo-controlled Phase II Study of BNC210 in Adults With Post-Traumatic Stress Disorder (PTSD).
适应症
干预措施
相关药物
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 193
- 主要终点
- Clinician-Administered PTSD Scale for the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) (CAPS-5), Total Symptom Severity Score
研究概览
简要总结
This is a randomized, double-blind, placebo-controlled study, evaluating the effects of BNC210 versus placebo on the symptoms of Post-Traumatic Stress Disorder, as measured by the Clinician-Administered PTSD Scale for DSM-5 (CAPS-5).
The secondary objectives of the study are to evaluate the effects of BNC210 on anxiety, depression, global functioning and patient reported outcomes in patients with PTSD. Safety and tolerability of BNC210 will also be assessed. Study participants will receive 12 weeks of blinded treatment followed by a 3 week follow-up period.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
盲法说明
Double blind
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Signed and dated informed consent.
- •Male or female between 18 and 70 years of age, inclusive.
- •Diagnosed with current PTSD as defined by the CAPS-5 for DSM-
- •Currently not using any psychiatric medications except for:
- •No more than one selective serotonin reuptake inhibitor (SSRI) (fluvoxamine is excluded) or serotonin noradrenaline reuptake inhibitor (SNRI) within the licensed prescribing dose range. Subjects must have been on a stable dose for at least 3 months prior and through Screening, with the intent to remain on the same dose through to Week
- •As needed (PRN) use of benzodiazepines (BZD) at a frequency not exceeding 2 days per week in the 3 months prior to Screening. The total dose must not exceed 30 mg/day in diazepam equivalents.
- •Subjects not currently receiving psychotherapy except long term supportive counseling or subjects that have received intensive regular psychotherapy for a minimum of three months prior to Screening.
- •Females of childbearing potential must have a negative serum pregnancy. Females not of childbearing potential must be postmenopausal. Sterilized male patients must be at least 1 year post-vasectomy to be considered of non-child bearing potential. Females and males of childbearing potential must agree to use two effective methods of contraception.
- •Key Exclusion Criteria
- •Current and ongoing exposure to the trauma that caused the PTSD.
- •Failed more than three trials of antidepressant medication(s) prescribed for the treatment of PTSD. Each trial must have lasted at least 6 weeks to be considered a failed attempt. A trial that was terminated due to intolerability or side effects does not constitute a failed attempt.
- •The use of psychiatric medications within 2 weeks of Screening except for SSRIs, SNRIs or limited PRN BZD use as per inclusion criterion
- •Restricted psychiatric medications include (but are not limited to) antidepressants not allowed by inclusion criterion 4, antianxiety drugs (except limited BZD use per inclusion criterion 4), mood stabilizers, stimulants, antipsychotics, hypnotics and acetylcholinesterase inhibitors.
- •History of significant traumatic brain injury.
- •Depression as measured by Montgomery-Äsberg depression scale (MADRS) rating >
- •Bipolar and psychotic disorders as identified at Screening using the MINI International Neuropsychiatry Interview (V7.0) (M.I.N.I).
- •A score ≥ 7 on the McLean Screening Instrument for Borderline Personality Disorder (MSI-BPD) at Screening.
- •History of seizure disorders, uncontrolled sleep apnoea or severe neurologic disease.
- •Increased risk of suicide, defined as:
- •Any previous suicide attempt disclosed by the participant at Screening using the Columbia Suicide Severity Rating Scale (C-SSRS).
- •Any suicidal ideation with intent (yes to item 4 and / or 5) or suicidal behavior in the past year, as captured at Screening using the C-SSRS.
- •A score > 4 on item 10 of the MADRS at Screening.
- •The use of alprazolam or flunitrazepam within 3 months of Screening.
- •Any clinically significant abnormalities in laboratory test results, vitals signs, or ECG at Screening.
- •Positive result for human immunodeficiency virus (HIV), hepatitis B surface antigen (HBsAg), or hepatitis C (HCV) at Screening.
- •Any moderate to severe substance use disorder (any type) in the 12 months prior to Screening as identified by the DSM-5 using the M.I.N.I (V7.0).
- •Current Australian serving Defense personnel or any member of the US military currently serving on active duty.
- •Participants involved with ongoing insurance or workplace claims that in the opinion of the Investigator are likely to have an impact on the mental health, presentation or capacity of the patient to engage in the study.
排除标准
- 未提供
研究组 & 干预措施
BNC210 600 mg b.i.d.
Experimental
Suspension administered orally for 12 weeks.
干预措施: BNC210 (Drug)
BNC210 300 mg b.i.d.
Experimental
Suspension administered orally for 12 weeks.
干预措施: BNC210 (Drug)
BNC210 150 mg b.i.d.
Experimental
Suspension administered orally for 12 weeks.
干预措施: BNC210 (Drug)
Placebo b.i.d.
Placebo Comparator
Suspension administered orally for 12 weeks.
干预措施: Placebo (Drug)
结局指标
主要结局
Clinician-Administered PTSD Scale for the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) (CAPS-5), Total Symptom Severity Score
时间窗: 12 weeks.
Investigator-rated PTSD symptom severity. The range for the Clinician-Administered PTSD Scale for the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) (CAPS-5)Total Symptom Severity Score is 0-80, with a higher score meaning a higher severity of disease.
次要结局
- Patient Global Impression - Improvement Scale (PGI-I).(12 weeks.)
- Montgomery- Åsberg Depression Rating Scale (MADRS).(12 weeks.)
- Clinical Global Impressions - Severity Scale (CGI-S).(12 weeks)
- Sleep Monitoring: Pittsburgh Sleep Quality Index (PSQI).(12 weeks.)
- Hamilton Anxiety Rating Scale (HAM-A).(12 weeks)
- Social Functioning: Sheehan Disability Scale (SDS).(12 weeks.)
- Post-Traumatic Stress Disorder (PTSD) Checklist for the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) (PCL-5).(12 weeks.)
- Patient Global Impressions - Severity Scale (PGI-S).(12 weeks.)
- CANTAB (Cambridge Neuropsychological Test Automated Battery) Cognitive Assessment(12 Weeks)
- Clinical Global Impressions - Improvement Scale (CGI-I).(12 weeks)
- Assessment of Quality of Life (AQoL-8D).(12 weeks.)
研究者
相似试验
已完成
2 期
A Phase 2 Study of BNC210 for the Acute Treatment of Social Anxiety DisorderSocial Anxiety DisorderNCT05193409Bionomics Limited151
已完成
2 期
A Study of BNC210 in Elderly Patients With AgitationAgitation in the ElderlyNCT03548194Bionomics Limited38
Unknown
4 期
Smoking Cessation Program in the Preadmission ClinicSmokingNCT00937508University Health Network, Toronto290
已完成
4 期
Study on the Effects of Intravenous Dexmedetomidine on Pain in Patients Undergoing Elective Spinal SurgeryChronic PainNCT03325972NYU Langone Health83
招募中
不适用
A Study to Evaluate Efficacy of EB-PA as Protein Amplifier for Skeletal Muscle Strength & GrowthSkeletal Muscle Strength & GrowthNCT06127849Vedic Lifesciences Pvt. Ltd.138