Preterm Resources, Education, and Effective Management for Infants
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 11,195
- 试验地点
- 2
- 主要终点
- 10% relative risk reduction in 28-day neonatal mortality rate in preterm infants
研究概览
简要总结
The purpose of this Quality Improvement initiative is to reduce severe morbidity and mortality among premature infants through proven and cost-effective clinical management during the antenatal, intrapartum, and postpartum periods. In order to reduce neonatal mortality and morbidity due to preterm birth complications, health facilities must be able to identify and manage women in preterm labor, accurately administer medications, and provide high-quality postnatal care.
详细描述
The purpose of this Quality Improvement initiative is to reduce severe morbidity and mortality among premature infants through proven and cost-effective clinical management during the antenatal, intrapartum, and postpartum periods. In order to reduce neonatal mortality and morbidity due to preterm birth complications, health facilities must be able to identify and manage women in preterm labor, accurately administer medications, and provide high-quality postnatal care.
The study will provide evidence of implementing a package of clinical interventions coupled with quality improvement and monitoring strategy aimed at reducing neonatal mortality in 3 resource-limited health facilities, leveraging on an existing strengthened birth registry to provide neonatal outcomes up to 28 days after delivery. Additionally, using a multifaceted approach through an interdisciplinary team, the investigators will identify the social and cultural barriers that contribute to home-based deliveries. These findings will be helpful to the Ministry of Health in shaping future policies regarding the scale-up of newborn care clinical protocols as part of Government's efforts to reducing neonatal mortality in Zambia.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 10 Years 至 —(Child, Adult, Older Adult)
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Pregnant women who seek Antenatal care services and plan to deliver in the selected health facilities
- •Women who reside within the larger catchment area of the selected 3 health facilities
排除标准
- •Women who reside outside the larger catchment area of the health facilities
- •Women who have not sought antenatal care services in the 3 health facilities and have come to only deliver there
结局指标
主要结局
10% relative risk reduction in 28-day neonatal mortality rate in preterm infants
时间窗: Baseline to 36 months
Rate of 28-day neonatal mortality at the end of the study compared to that at baseline
次要结局
- 20% relative risk reduction in all-cause 7-day neonatal mortality in preterm infants(Baseline to 36 months)
- Factors that contribute to home and facility deliveries within the PREEMI facility catchment areas through the use of pre-determined questionnaire.(Baseline to 36 months)
研究者
Albert Manasyan
Assistant Professor
University of Alabama at Birmingham
