Impact of Early Aging and Menopause on the Vascular Responses to Hypoxia
试验速览
- 阶段
- 1 期
- 状态
- 招募中
- 入组人数
- 75
- 试验地点
- 2
- 主要终点
- Forearm blood flow
研究概览
简要总结
The purpose of this study is to examine hypoxic vasodilation and the role of beta-adrenergic receptors in younger premenopausal, perimenopausal, and older postmenopausal women.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Female assigned at birth
- •Pre, peri- or post-menopausal
- •Healthy weight (BMI ≥18 and ≤30 kg/m2)
排除标准
- •Male (assigned at birth)
- •Pregnancy, breastfeeding
- •Use of hormone replacement therapies
- •Hysterectomy
- •Body mass index >30 kg/m2
- •Diagnosed sleep apnea
- •Current smoking/Nicotine/Drug use
- •Nerve/neurologic disease
- •Cardiovascular, hepatic, renal, respiratory disease
- •Blood pressure ≥140/90 mmHg
- •Diabetes, Polycystic ovarian syndrome
- •Communication barriers
- •Prescription medications
- •Malignant cancer
研究组 & 干预措施
Cold pressor test
Participants will be exposed to the cold pressor test (ice water on the foot).
干预措施: Propranolol (Drug)
Hypoxia
Participants will be exposed to hypoxia (low oxygen air) using a mask.
干预措施: Propranolol (Drug)
Hypercapnia
Participants will be exposed to hypercapnia (high carbon dioxide air) using a mask.
干预措施: Placebo (Drug)
Cold pressor test
Participants will be exposed to the cold pressor test (ice water on the foot).
干预措施: Gemtesa (Drug)
Hypoxia
Participants will be exposed to hypoxia (low oxygen air) using a mask.
干预措施: Placebo (Drug)
Cold pressor test
Participants will be exposed to the cold pressor test (ice water on the foot).
干预措施: Placebo (Drug)
Hypoxia
Participants will be exposed to hypoxia (low oxygen air) using a mask.
干预措施: Gemtesa (Drug)
Hypercapnia
Participants will be exposed to hypercapnia (high carbon dioxide air) using a mask.
干预措施: Propranolol (Drug)
Hypercapnia
Participants will be exposed to hypercapnia (high carbon dioxide air) using a mask.
干预措施: Gemtesa (Drug)
结局指标
主要结局
Forearm blood flow
时间窗: Change from baseline to 5 minutes.
Blood flow in the forearm measured with venous occlusion plethysmography.
次要结局
未报告次要终点
研究者
Jacqueline K Limberg, PhD
Associate Professor
University of Missouri-Columbia