Characteristics and Evolution of Diabetes Mellitus in Mexican Children: Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 500
- 试验地点
- 1
- 主要终点
- Peripheral diabetic neuropathy
研究概览
简要总结
The aim of this study is the identification of complications in diabetes mellitus pediatric patients and to compare the clinical, anthropometric, and biochemical characteristics between children in the different types of diabetes mellitus.
详细描述
Diabetes mellitus is characterized by hyperglycemia resulting from defects in insulin secretion and/or insulin resistance in target tissues. This study identify the influence of pathogenic factors on the evolution of diabetes mellitus and in the presence of chronic complications.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 1 Month 至 17 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with confirmed diagnosis of diabetes mellitus
排除标准
- 未提供
结局指标
主要结局
Peripheral diabetic neuropathy
时间窗: year 5
A microvascular complication determined by neurological exam in either foot
Microalbuminuria
时间窗: annual
A microvascular complication determined by urine albumin excretion \>= 30 mg/day
Cognitive evaluation
时间窗: year 3
Determined by scores on the Mini-Mental State Examination
Diabetic retinopathy
时间窗: year 3
A microvascular complication determined by ophthalmological evaluation
Nerve damage
时间窗: year 5
A microvascular complication determined by nerve conduction study in either foot
Cardiac function
时间窗: year 5
A cardiovascular risk indicator determined by echocardiogram
Intelligence quotient evaluation
时间窗: year 3
Determined by Intelligence quotient test
次要结局
- Glycemic control(annual)
- Pancreatic autoimmunity(onset of diabetes)
- Body composition(annual)
- Beta cell function(annual)
- Alpha cell function(year 5)
- Hyperlipidemia(annual)
- Hypothyroidism(annual)
- Insulin resistance(annual)
- Hypertension(annual)
研究者
Maria Lola Evia-Viscarra
Pediatric Endocrinologist
Hospital Regional de Alta Especialidad del Bajio