Preoperative Therapeutic Plasma Exchange and Surgical Treatment in Thyrotoxicosis Patients: a Single-centre Retrospective Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 27
- 主要终点
- Thyroid hormone levels of patients after therapeutic plasma exchange
研究概览
简要总结
Therapeutic plasma exchange (TPE) is indicated in cases where antithyroid medications cannot be used due to the side effects or attain no adequate hormonal suppression response at the highest dosage and in cases of rapid onset of clinical symptoms. This study presents the treatment results of patients who underwent TPE and subsequently operated for thyrotoxicosis.
详细描述
Background: Therapeutic plasma exchange (TPE) is indicated in cases where antithyroid medications cannot be used due to the side effects or attain no adequate hormonal suppression response at the highest dosage and in cases of rapid onset of clinical symptoms. This study presents the treatment results of patients who underwent TPE and subsequently operated for thyrotoxicosis.
Methods: The files of 27 patients who underwent preoperative TPE for thyrotoxicosis between January 1999 and February 2019 were retrospectively analyzed. The demographic and clinical features of the patients were included.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •thyrotoxicosis unresponsive to medication
- •adverse reaction to the medications
- •need for rapid treatment in patients that need urgent surgery
排除标准
- •The patients who did not undergo surgery post-therapeutic plasma exchange
- •Preoperative hypocalcemia,
- •hemodynamically unstable patients
- •patients not suitable for central catheter placement
结局指标
主要结局
Thyroid hormone levels of patients after therapeutic plasma exchange
时间窗: 1 week before the operation
Concentration of serum thyroid hormone levels before thyroidectomy
次要结局
未报告次要终点
研究者
İlker Murat Arer
Associate Professor Hakan Yabanoglu
Baskent University