NCT01009632已完成不适用
Role of Exercise for Wound Healing in the Larynx
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 9
- 试验地点
- 2
- 主要终点
- Biomarkers in laryngeal secretions
研究概览
简要总结
The purpose of this study is to explore quantitatively the hypothesis that "resonant voice," may enhance recovery from acute laryngeal phonotrauma, based on molecular assays from human laryngeal secretions and secondarily, clinical tests.
详细描述
The objective is to use the following operationalized question: Does a voicing mode shown to correspond to high-amplitude, low impact vocal cord oscillations, "resonant voice," improve the amount and time-course of recovery from acute phonotrauma, compared to vocal rest or spontaneous speech, as measured with molecular assays (primarily) and with behavioral and clinical tests (secondarily)?
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Factorial
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 49 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •males and females who have had voice training and feel they are able to produce loud voice safely;
- •ages 18-49;
- •generally healthy;
- •normal hearing bilaterally at 20 dB to 8,000 Hz; and
- •demonstrated ability to produce "resonant voice" during training as determined by the examiner perceptually.
排除标准
- •current chronic voice problems;
- •current medications that are determined to possibly influence voice (e.g. diuretics, decongestants);
- •heightened gag reflex;
- •small nasal passage;
- •deviated septum; and
- •known or suspected allergy to anesthetics.
结局指标
主要结局
Biomarkers in laryngeal secretions
时间窗: Up to 24-hour post-baseline
次要结局
- Direct Magnitude Estimations of phonatory effort (DME)(Up to 24-hour post baseline)
- Visual-perceptual ratings of the larynx(Up to 24-hour post baseline)
- Phonation Threshold Pressure (PTP)(Up to 24-hour post baseline)
研究者
研究点 (2)
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