To compare the hemodynamic effects of low dose intrathecal bupivacaine with 25 microgram butorphanol in cardiac versus non cardiac patients.

Shri Guru Ram Das institute of health sciences and research0 个研究点目标入组 0 人开始时间: 待定最近更新: 2021年11月24日

试验速览

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•Cardiac patients of either sex belonging to
•ASA grade II and III
•Patients with intermediate clinical predictors with moderate or excellent functional capacity (METS >4) undergoing intermediate or low risk surgical procedures.
•Patients with intermediate clinical predictors with poor functional capacity (METS <4) undergoing low/intermediate risk surgical procedures if non invasive testing suggests a low cardiac risk.
•Patients with minor or no clinical predictors with moderate or excellent functional capacity (METS >4) undergoing intermediate or low risk surgical procedures.
•Non cardiac patients will be ASA grade I and II.

•1. Patientâ??s refusal to participate in the study.
•2. Pregnancy
•3. ASA grade IV for cardiac patients and ASA grade III and IV for non cardiac patients.
•4. Patients in acute decompensated left/right ventricular failure, pulmonary edema
•5. Severe reduction in LVEF of <30%
•6. BMI > 30
•6. Patients with contraindications to SAB such as local infections at the site of lumbar puncture, severe spinal deformity, severe hypovolemia , increased intra-cranial pressure (i.e. brain tumor or recent head injury)
•7. Patients with active chest infection
•8. Patients with major clinical predictors: unstable coronary syndromes, decompensated CHF, significant arrhythmias (2nd and 3rd degree atrio-ventricular block, symptomatic ventricular arrhythmias, supraventricular arrhythmias with uncontrolled ventricular rate), severe valvular diseases like severe aortic/mitral stenosis)
•9. Severe uncorrected anemia
•10. Patients with known coagulopathies.
•11. Deranged coagulation profile INR >1.5 and aPTT >40.
•12. Patients with history of drug allergy to opioids/local anaesthetics.
•13. Patients with bare metal stent < 4-6 weeks ago and drug eluting stents < 12 months ago.
•14. Patients having intermediate/minor or no clinical predictors presenting for high risk surgical procedures.
•15. Patients with no clinical predictors having high cardiac risk on non invasive testing.

发起方

Shri Guru Ram Das institute of health sciences and research