Impact of Endothelial Cell Activation and Modifications of Haemostasis Induced by Infective Endocarditis on the Risk of Embolism.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 77
- 试验地点
- 1
- 主要终点
- Embolic events occurring during the antimicrobial treatment a
研究概览
简要总结
Prospective study including all the consecutive patients admitted at the Department of Cardiology, Timone Hospital wih a definite diagnosis of IE according to the modified Duke criteria. The period of inclusion will be for 24 months. Eighty patients and age-matched control subject will be included. Primary end point are EE occurring during the antimicrobial treatment and secondary end points will be 6-month mortality, vegetation length and the impact of antimicrobial treatment on inflammation-induced procoagulant changes and endothelial cell activation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •All the patients presenting certain diagnosis of infectious endocardite according to the criteria of modified Duke
排除标准
- •Age < 18 years
- •Pregnancy and feeding
- •Health not allowing to give the assent
- •Innate abnormalities of the haemostasis
- •More than a week before the inclu antibiothérapie adapted begun
研究组 & 干预措施
control
干预措施: ULTRASONOGRAPHY trans-esophageal and trans-thoracic , blood test and clinic test (Other)
patient
干预措施: ULTRASONOGRAPHY trans-esophageal and trans-thoracic , blood test and clinic test (Other)
结局指标
主要结局
Embolic events occurring during the antimicrobial treatment a
时间窗: 30 months
次要结局
- Will be 6-month mortality, vegetation length and the impact of antimicrobial treatment on inflammation-induced procoagulant changes and endothelial cell activation.(30months)