Genetics of Appendix Cancer: The GAP Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 700
- 试验地点
- 1
- 主要终点
- Prevalence and spectrum of pathogenic and likely pathogenic germline variants in appendix cancer patients and their biological parents
研究概览
简要总结
The GAP Study is a prospective cohort study designed to comprehensively investigate genetic variations that may contribute to cancer development among individuals diagnosed with appendix/appendiceal cancer who are ages 18+ years.
详细描述
The Genetics of Appendix Cancer (GAP) Study aims to analyze hereditary factors, tumor characteristics and clinical features/outcomes among adults diagnosed with appendix cancer and their biological parents. Patients are recruited at any time after a diagnosis of appendix cancer and followed for up to 6 years after study enrollment. This cohort is enriched by robust biospecimens and data collections.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Known diagnosis of appendix cancer in the United States
- •Mentally and physically able to consent and participate in the study
- •GAP Vanderbilt
- •Known diagnosis of appendix cancer
- •Diagnosed by and/or consulting with a physician/clinical provider participating in the GAP Study
- •Mentally and physically able to consent and participate in the study
- •Biological parents (mother and/or father) of individuals actively participating in the GAP Study
- •Residing in the United States
- •Mentally and physically able to consent and participate in the study
排除标准
- •Women pregnant at the time of consent
- •Prisoners
- •Unable to provide informed consent
- •Unable to read, write, or complete questionnaires in English
结局指标
主要结局
Prevalence and spectrum of pathogenic and likely pathogenic germline variants in appendix cancer patients and their biological parents
时间窗: Within 6 years of study enrollment
次要结局
- Association of germline genetic variants with clinical, pathologic and molecular features of appendix tumors(Within 6 years of study enrollment)
研究者
Andreana Holowatyj, PhD, MSCI
Sponsor Investigator
Vanderbilt-Ingram Cancer Center