Role of the Isomerase Pin-1 in the Development and Treatment of Asthma
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 14
- 试验地点
- 2
- 主要终点
- Change From Baseline in the Percentage of Total White Blood Cell That Were Eosinophils at 48 Hours
研究概览
简要总结
Pin1 is activated in asthmatic airways, increasing cytokine mRNA stability and eosinophil survival. This study is designed to test whether the Pin1 enzyme regulates TLR/IL-1R signal pathways in multiple cells in asthma.
详细描述
The investigators will test their hypothesis that Pin1 regulates TLR/IL-1R signaling pathways in asthma by examining Pin1 and related pathway activation in BAL-derived eosinophils after house dust mite allergen challenge. The investigators will perform segmental allergen challenge. BAL and lung biopsy of the allergen-challenged segments will be performed 48 hr later and activation of Pin1 and related pathways will be examined.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Change From Baseline in the Percentage of Total White Blood Cell That Were Eosinophils at 48 Hours
时间窗: from baseline to 48 hours
Measure Pin1 activity in BAL-derived eosinophils after House Dust Mite (HDM) allergen challenge: Eosinophils post-challenge change from pre-challenge is reported: absolute change = \[eosinophils post (%) - eosinophils pre (%)\]
次要结局
- Percent Change From Baseline in the Percentage of Total White Blood Cell That Were Lymphocytes at 48 Hours(from baseline to 48 hours)
- Percent Change From Baseline in the Percentage of Total White Blood Cell That Were Macrophages at 48 Hours(from baseline to 48 hours)
- Change From Baseline in the Percentage of Total White Blood Cell That Were Neutrophils at 48 Hours(from baseline to 48 hours)
研究者
Elliot Israel, MD
Physician
Brigham and Women's Hospital