The Effect of Dosage of Caffeine on Intraocular Pressure in Healthy Subjects
试验速览
- 阶段
- 不适用
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- change from baseline in intraocular pressure (mmHg)after caffeine intake
研究概览
简要总结
The goal of the study is to determine the effect of different doses of caffeine on intraocular pressure. We hypothesized that higher dosage of caffeine would increase intraocular pressure more than lower doses.
Eligible subjects will be randomized into three groups:
- group 1: intake of decaffeinated coffee
- group 2: intake of coffee with lower caffeine dose
- group 3: intake of coffee with higher caffeine dose
Intraocular pressure will be measured at 0, 30, 60 and 90 minutes after coffee intake.
详细描述
decaffeinated coffee contains 0.5-2 mg of caffeine regular dose coffee contains 91.8 mg of caffeine high dose coffee contains 144 mg of caffeine
all three groups' intraocular pressure will be measured with the Goldmann applanation tonometer at 4 timepoints:
- 0 minutes (baseline)
- 30 minutes after intake
- 60 minutes after intake
- 90 minutes after intake
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy subjects
- •normal central corneal thickness
- •normal baseline intraocular pressure
排除标准
- •any ocular disease
- •baseline intraocular pressure over 21 mmHg
- •central corneal thickness less than 520 microns or more than 540 microns
结局指标
主要结局
change from baseline in intraocular pressure (mmHg)after caffeine intake
时间窗: 0, 30 minutes, 60 minutes, 90 minutes post-caffeine intake
intraocular pressure measured at 4 timepoints: 1. 0 minutes (baseline) 2. 30 minutes after intake 3. 60 minutes after intake 4. 90 minutes after intake
次要结局
未报告次要终点
研究者
Damrong Wiwatwongwana
M.D.
Chiang Mai University