NCT02821286Enrolling By Invitation不适用
Identification of Anaphylactogenic Antibodies in the Blood of Peanut Allergic Patients
适应症
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 入组人数
- 100
- 主要终点
- Analysis and profiling of specific antibodies against major peanut allergens in samples derived from peanut allergic patients.
研究概览
简要总结
This project intends the analysis and profiling of specific antibodies against major peanut allergens in peanut allergic individuals and molecular cloning of human antibodies against major peanut allergens.
详细描述
- Characterization of patient samples reactivity (sera obtained from blood) against major peanut allergens.
- Isolation of antibody-producing B cells.
- Molecular cloning of peanut-specific antibodies from antibody gene sequences obtained from B cells.
- Biophysical and functional characterization of isolated antibodies
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 3 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Participants have a described clinical history of peanut allergy and/or are sensitized to peanut allergens (as evidenced by positive skin prick test and allergen-specific IgE testing)
- •Male and female subjects older than 3 years
- •Written informed consent
排除标准
- •age below three years
- •patients suffering from any disease where blood withdrawals might impact the patients' health status such as known anemia.
结局指标
主要结局
Analysis and profiling of specific antibodies against major peanut allergens in samples derived from peanut allergic patients.
时间窗: June 2016 to May 2018
次要结局
未报告次要终点
研究者
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