Proteomic Analysis in Sera From Patients With Erosive Hand Osteoarthritis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 32
- 试验地点
- 1
- 主要终点
- Quantification by label-free proteomic analysis of the serum of patients affected by hand osteoarthritis
研究概览
简要总结
Hand osteoarthritis is a common phenotype of osteoarthritis which affects about 70 % of the elderly population. Usually considered as a minor illness, it nevertheless leads to an important functional impairment. The mechanism of this disease is still poorly known. Furthermore there are 2 different subtypes : erosive and non erosive hand osteoarthritis from which mechanisms may differ.
Methods:
This is a cross-sectional study recruiting patients with hand osteoarthritis addressed in consultation of rheumatology and plastic surgery in Rouen University Hospital.
Two groups of patients will be studied: 20 patients with non erosive subtype of hand osteoarthritis and 20 patients with erosive subtype of hand osteoarthritis.
A clinical evaluation of hand osteoarthritis will be performed. Blood sample for proteomic analysis will be taken. Hand MRI and Bone Mineral Analyser will be performed.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Female gender
- •Less than 70 years old
- •Diagnosis of hand osteoarthritis according to ACR criteria ACR after exclusion of thumb base osteoarthritis:
- •Hand pain, aching or stiffness most of the days during the preceding month
- •Hard tissue enlargement of at least two of 8 selected joints *
- •Hard tissue enlargement of at least two distal interphalangeal joint
- •Swelling of fewer than three metacarpophalangeal joint
- •Deformity of at least one of 10 selected joints * Patients have to fulfil criteria 1, 2 AND 3 + 4 OR 5 * the 8 selected joints are the second and third distal interphalangeal joint and the second and third proximal interphalangeal of both hands Then confirm by experts' committee
- •Exclusively symptomatic treatment
- •For women of child-bearing age, use of an effective contraceptive method
- •French spoken and read
排除标准
- •Male gender
- •More than 70 years old
- •Hemochromatosis
- •Inflammatory arthritis
- •Cristal induced arthritis
- •Active diseases such as infection or cancer
- •Use of DMARDs
- •Pregnant or breast-feeding woman
结局指标
主要结局
Quantification by label-free proteomic analysis of the serum of patients affected by hand osteoarthritis
时间窗: day 1
Assessments done using biological sampling
次要结局
- Number of Erosion in patients affected by hand osteoarthritis(Day 1)