A Study for the Ocular Toxocariasis in the Patients Who Were Diagnosed With the Pulmonary Toxocariasis, and Ocular Toxocariasis Cohort: TOXOCARA Study
试验速览
- 阶段
- 不适用
- 入组人数
- 400
- 试验地点
- 1
- 主要终点
- Number of patients with ocular toxocariasis (OT)
研究概览
简要总结
TOXOCARA Study is a prospective observational cohort study. The aim of this study is to evaluate the incidence of ocular toxocariasis (OT) associated with pulmonary toxocariasis (PT) in patients with chest diagnostic image tests (chest X-ray, chest CT) with migrating ground glass opacity or nodular lesions. Also a cohort study is to track the results of treatment for diagnosed ocular toxocariasis (OT) patients.
详细描述
Toxocara canis (also known as dog roundworm) is wide-reaching parasite of dogs and other canids. It can spread between animals such as cats, pigs and cows by ingestion of worm eggs from the feces of an infected animal.
In humans, two pathways of infection are known: first, ingestion of the eggs and second, larvae encapsulated in the tissues of the infected animal.
The encapsulated larvae hatch in the small intestine and pass through the barrier to the portal vein, the liver, the lung, the eye, etc. and remain as encapsulated larvae or survive for a period of time.
Infection into humans has been reported through ingestion of uncooked liver of cows, pigs, sheep, chickens, and meat (muscle).
When encapsulated larvae migrate to the body such as lungs, eosinophils activate and proliferate to eliminate the parasites.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Aged 18 years and older
- •Patient who has positive result of Toxocara Ab
- •Patient who has history of eating of law animal liver or meat
- •Patient who has the chest diagnostic image tests (chest X-ray, chest CT) with migrating ground glass opacity or nodular lesions.
排除标准
- •Age < 18 years
- •Pregnant woman
- •Malignant patient
- •Patient who has pulmonary infectious lesion such as pneumonia, fungus and tuberculosis
- •Patients who were diagnosed by benign or malignant pulmonary nodule
- •Patient who was not consented
结局指标
主要结局
Number of patients with ocular toxocariasis (OT)
时间窗: at baseline
Patients who have the clinical manifestation of intraocular infection by Toxocara larvae and a positive result of serum toxocara Ab and history of eating of law animal liver or meat. (and/or migrating pulmonary GGOs or nodular lesions) or history of having the pets such as dogs and cats.
Number of patients with pulmonary toxocariasis (PT)
时间窗: at baseline
Patients who have a positive result of serum toxocara Ab and migrating pulmonary GGOs or nodular lesions and history of eating of law animal liver or meat or history of having the pets such as dogs and cats.
Number of patients with ocular toxocariasis (OT) among the patients with pulmonary toxocariasis (PT),
时间窗: at baseline
Patients who have ocular toxocariasis (OT) with pulmonary toxocariasis (PT)
次要结局
- Clinical course of the patients with ocular toxocariasis (OT) after treatment(3 years)
- Incidence of Clonorchiasis(at baseline)
- Incidence of Sparganosis(at baseline)
- Incidence of Cysticercosis(at baseline)
- Incidence of Paragonimiasis(at baseline)
- Incidence of Anisakiasis(at baseline)
研究者
Kwang Won Seo
Associate professor, division of pulmonology, dept. of internal medicine
University of Ulsan