Prognostic Interest of Vasorin in Septic Shock
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- correlation between vasorin concentration at day 3 and mortality rate
研究概览
简要总结
In septic shock, the intensity and duration of low blood pressure can lead to a critical reduction in renal tissue perfusion and lead to the onset of more or less severe Acute Kidney Injury (AKI). Vasorin (Vasn) is a protein strongly expressed in large vessels and kidneys, whose functions are still poorly known. Previous experimental studies show that Vasn is associated with decreased Angiotensin II concentrations, a vessel contractility defect and early mortality.
The investigators hypothesize that Vasn (the potential direct regulator of blood pressure) would be an early biomarker predicting the severity of AKI post septic shock, which may be associated with mortality from septic shock or lead to longer-term Chronic Renal Failure (CKD).
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥18 years old.
- •Hospitalized in intensive care or medical resuscitation units.
- •With a septic shock state defined by 2 mmol/l lactate sepsis, requiring vasopressors to maintain mean blood pressure 65 mmHg (despite adequate vascular filling).
- •Whether or not they have developed AKI.
- •Patient/family information and collection of non opposition
排除标准
- •Patients with chronic respiratory failure.
- •Pregnant women.
- •Patients in palliative care.
- •Information for the patient/someone close and collection of his opposition
结局指标
主要结局
correlation between vasorin concentration at day 3 and mortality rate
时间窗: day 3
correlation between vasorin concentration at day 0 and mortality rate
时间窗: day 0
次要结局
未报告次要终点