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临床试验/NCT02393729
NCT02393729已完成不适用

Functional MRI Study of the Involvement of Cortico-cerebellar and Cortico-striatal Networks in Children With a Developmental Coordination Disorder (DCD) and/or Developmental Dyslexia (DD)

University Hospital, Toulouse1 个研究点 分布在 1 个国家目标入组 65 人开始时间: 2011年1月1日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
入组人数
65
试验地点
1
主要终点
difference in the level of brain activity

研究概览

简要总结

All the studies underlined the high frequency of co-morbid associations in specific learning disorders. Understanding the reasons for these associations could enable us to determine the cerebral bases that underlie each disorder. Their frequent association suggests the etiological bases are partly common, it seems logical to turn to explanatory models of various common specific disorders. The model recently proposed by Nicholson & Fawcett (2007) suggests a specific disorder of procedural learning. But the brain networks involved in this learning could be achieved separately. We intend therefore to study the neural networks involved in learning procedural and compare networks recruited among children with specific learning disorder alone or in combination (co-morbidity). The children included in the study have either a Developmental Dyslexia or a Developmental Coordination Disorder, or both. The procedure includes a neuropsychological evaluation and a brain MRI study with a morphological and a functional part. During fMRI the child realizes a automated motor task contrasting with a task involving learning procedural.

研究设计

研究类型
Interventional
分配方式
Non Randomized
干预模型
Parallel
主要目的
Other
盲法
None

入排标准

年龄范围
8 Years 至 12 Years(Child)
性别
All
接受健康志愿者
是

入选标准

  • •These children presenting either a specific disorder in learning to read (developmental dyslexia or DD) type phonological or mixed as defined by World Health Organisation or a Developmental Coordination Disorder (DCD) as defined by Diagnostic and Statistical Manual IV criteria or the association of both disorders (DCD + DD).
  • •Or in the control group:
  • •Children having no neurological or psychiatric disorder, mental retardation with IQ (Intelligence quotient) > 70 and DCD (score> 15 percentile on the Movement ABC) and Dyslexia (reading delay should not exceed 12 months) The age of children included in the study is between 8 and 12 years. The inclusion of subjects from 8 years is justified to have an optimal level of cooperation of the child in the MRI, in order to determine the status of children for reading and the fact that most of validated neuropsychological tests for reading are for the age 8 to 12 years.
  • •Children and their parents must have given their free and informed consent signed. The representative of the child shall be affiliated to a social security scheme.
  • •The children included in the study will be all right handed.

排除标准

  • •Mental retardation as defined by DSM IV criteria by an estimated IQ from the Wechsler scales less than
  • •The presence of a Specific Language Impairment (or dysphasia): a score below -2 SD (standard deviation) in at least one of three tests for language assessment is a criterion for exclusion.
  • •The presence of a dyslexia-type surface defined by a specific disorder in learning to read without difficulty for metaphonological tests and/or an exclusive impairment of the addressing reading route (reading irregular words).
  • •Children regularly practicing a musical instrument conferring a high manual dexterity such as piano or guitar.
  • •Children with neurological or psychiatric disorders as epilepsy for example. Children under psychotropic medication such as anticonvulsant. Treatment with methylphenidate is not an exclusion criterion but treatment should be discontinued at least 48 hours before performing MRI. Children with ADHD according to DSM IV criteria.
  • •The presence of a cons-indication for a MRI.

研究组 & 干预措施

children with DCD

Other

Children with Developmental Coordination Disorder (DCD) will have neuropsychological assessment and MRI study

干预措施: Neuropsychological assessment (Behavioral)

children with DCD

Other

Children with Developmental Coordination Disorder (DCD) will have neuropsychological assessment and MRI study

干预措施: MRI Study (Other)

children with DD

Other

Children with Developmental Dyslexia (DD) will have neuropsychological assessment and MRI study

干预措施: Neuropsychological assessment (Behavioral)

children with DD

Other

Children with Developmental Dyslexia (DD) will have neuropsychological assessment and MRI study

干预措施: MRI Study (Other)

children with DCD + DD

Other

Neuropsychological assessment and MRI study

干预措施: Neuropsychological assessment (Behavioral)

children with DCD + DD

Other

Neuropsychological assessment and MRI study

干预措施: MRI Study (Other)

control children

Other

Neuropsychological assessment and MRI study

干预措施: MRI Study (Other)

control children

Other

Neuropsychological assessment and MRI study

干预措施: Neuropsychological assessment (Behavioral)

结局指标

主要结局

difference in the level of brain activity

时间窗: 1 day

The difference in the level of brain activity obtained by contrasting the result of the automated task and that task with learning in the same patient-adjusted performance.

The level of brain activity obtained by fMRI

时间窗: 1 day

The level of brain activity obtained by fMRI will be estimated by the blood flow in milliliters per minute using a standardized procedure and validated specific MRI used and managed entirely by dedicated software (SPM8 - Welcome Department of Cognitive Neurology, London, UK). The performance adjustment is made in the analysis of the estimated difference in blood flow using a mixed model. Regions of interest are the primary motor cortex, the supplementary motor area, the pre motor cortex, the striatum and the cerebellum. These regions will be studied in both hemispheres.

次要结局

  • The performance of subjects(1 day)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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