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临床试验/CTRI/2024/10/076093
CTRI/2024/10/076093
招募中
不适用

Clinical outcomes of head and neck cancers comprehensively treated with radical intent at HBCHRC Vishakhapatnam- A Retrospective Analysis

Homi Bhabha Cancer Hospital and Research Center, Tata Memorial Centre, Visakhapatnam1 个研究点 分布在 1 个国家目标入组 600 人开始时间: 2024年11月11日最近更新:

概览

阶段
不适用
状态
招募中
发起方
Homi Bhabha Cancer Hospital and Research Center, Tata Memorial Centre, Visakhapatnam
入组人数
600
试验地点
1
主要终点
To assess clinico-epidemiological profile and outcomes of head and neck cancer patients comprehensively treated with radical intent at HBCHRC Vishakhapatnam

概览

简要总结

Head and neck cancers (HNC) are a heterogeneous group of cancers involving mucosal surfaces of the lip, tongue, oral cavity or mouth, oropharynx, nasopharynx, hypopharynx, pharynx not otherwise specified and larynx. Head and neck squamous cell carcinoma (HNSCC) accounts for more than 0.9 million cases and 0.4 million deaths worldwide.In India, there are more than 0.22 million cases and 0.12 million deaths according to the GLOBOCAN, 2020. Cancers of the lip and oral cavity are the second most common cancers following breast cancer. HNC constitutes 10.4% of the cancer burden and they account for 16.1% of cases in males and 4.8% of the cases in females. Information on cancer patterns and survival is essential for effective planning of cancer control interventions. Hence, we aimed at studying the clinico-epidemiological profile of HNC patients admitted in hospital from 2021 to 2023 and also to estimate the survival rate in them.

This is a retrospective study with duration of 1 year and recruiting all the patients treated between 1st January, 2021 and 31st December, 2023 at Homi Bhabha Cancer Hospital and Research Centre, Visakhapatnam.  Head and neck cancer patients who were treated comprehensively (received entire treatment in HBCH&RC) with radical intent will be included in our study. Outcomes will be measured as: Overall survival, Disease free survival, locoregional control, Pattern of care and Patterns of failure.

研究设计

研究类型
Observational

入排标准

年龄范围
12.00 Year(s) 至 90.00 Year(s)(—)
性别
All

入选标准

  • All head and neck cancer patient comprehensively (received entire treatment in HBCH&RC) treated with radical intent at HBCH&RC.

排除标准

  • Received at least one radical intent of treatment outside HBCH&RC
  • Treated with palliative intent.

结局指标

主要结局

To assess clinico-epidemiological profile and outcomes of head and neck cancer patients comprehensively treated with radical intent at HBCHRC Vishakhapatnam

时间窗: 2 years

次要结局

  • To assess the locoregional control (LRC)(2years)
  • To assess disease free survival (DFS)(2years)
  • To assess Overall survival (OS)(2years)
  • To assess p16 positivity by IHC(2years)
  • To assess acute & late toxicities(2years)
  • To find out prognostic factors associated with LRC, DFS & OS(2years)

研究者

发起方
Homi Bhabha Cancer Hospital and Research Center, Tata Memorial Centre, Visakhapatnam
申办方类型
Research institution and hospital
责任方
Principal Investigator
主要研究者

Dr Umesh Mahantshetty

Homi Bhabha Cancer Hospital and Research Center

研究点 (1)

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