Investigation of the Relationship Between rs671 Polymorphism and Attitudes and Behaviors Toward Drinking and Effectiveness of Health Education
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 622
- 试验地点
- 1
- 主要终点
- Change From Baseline in Drinking Frequency at One Month
研究概览
简要总结
Alcohol intolerance is common in East Asian populations and is strongly influenced by the rs671 variant in the ALDH2 gene. This study examined the associations of ALDH2 genotype with drinking behavior and alcohol-related reactions among Taiwanese university students. Participants with previous alcohol exposure underwent rs671 genotyping and received their individual genotype results together with the same standardized health education materials about alcohol intolerance and related health risks. Drinking behavior, knowledge, and attitudes were assessed before and one month after the intervention. The study also evaluated whether facial flushing and rapid heartbeat could help identify ALDH2 deficiency. Changes over the one-month period were evaluated overall and by genotype group.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Currently enrolled as a student at National Taiwan University
- •Aged 18 to 65 years
排除标准
- 未提供
研究组 & 干预措施
Genotype Feedback and Health Education
Participants underwent ALDH2 rs671 genotyping and received their individual genotype results together with the same standardized health education materials about alcohol intolerance, alcohol-related reactions, and associated health risks. Drinking behavior, knowledge, and attitudes were assessed at baseline and one month after the intervention.
干预措施: Individual ALDH2 Genotype Feedback (Behavioral)
Genotype Feedback and Health Education
Participants underwent ALDH2 rs671 genotyping and received their individual genotype results together with the same standardized health education materials about alcohol intolerance, alcohol-related reactions, and associated health risks. Drinking behavior, knowledge, and attitudes were assessed at baseline and one month after the intervention.
干预措施: Standardized Alcohol Health Education (Behavioral)
结局指标
主要结局
Change From Baseline in Drinking Frequency at One Month
时间窗: Baseline to one month after receipt of genotype feedback and health education
Drinking frequency was assessed using a study-specific questionnaire with ordinal response categories reflecting the number of drinking occasions per month. The change score was calculated from the baseline and one-month responses according to the prespecified questionnaire coding.
Change From Baseline in Alcohol Consumption per Drinking Occasion at One Month
时间窗: Baseline to one month after receipt of genotype feedback and health education
Alcohol consumption per drinking occasion was assessed using ordinal categories of 1-2, 3-4, or 5 or more alcohol units. One alcohol unit was calculated as \[beverage volume (mL) × alcohol by volume (%)\]/1000. The change score was calculated from the baseline and one-month responses.
Change From Baseline in Drinking Attitude Score at One Month
时间窗: Baseline to one month after receipt of genotype feedback and health education
Attitudes toward drinking were assessed using six study-specific statements rated on a five-point Likert scale from strongly disagree to strongly agree. Items were coded according to the prespecified scoring method and summed to produce a total attitude score, with higher scores indicating healthier attitudes toward alcohol use.
Change From Baseline in Alcohol Intolerance Knowledge Score at One Month
时间窗: Baseline to one month after receipt of genotype feedback and health education
Knowledge was assessed using a study-specific questionnaire covering alcohol metabolism, symptoms of alcohol intolerance, related health risks, diagnosis, treatment, and prevalence. The total score was calculated from correct responses, with higher scores indicating greater knowledge.
次要结局
未报告次要终点