NCT03434821已完成不适用
Impact of Hyperoxemia on Incidence of Ventilator-associated Pneumonia
University Hospital, Lille1 个研究点 分布在 1 个国家目标入组 534 人开始时间: 2018年3月15日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 534
- 试验地点
- 1
- 主要终点
- VAP occurrence
研究概览
简要总结
The aim of this prospective cohort single-center observational study is to determine the impact of hyperoxemia on ventilator-associated pneumonia (VAP) occurrence.
- SpO2 will be continuously recorded in order to determine the percentage of time spent with hyperoxemia.
- Patients with VAP will be prospectively identified.
- Patient characteristics and risk factors for VAP will be prospectively collected.
- Oxidant stress will be prospectively investigated in study patients: glutathion peroxidase (GPX), plasmatic superoxyde dismutase (SOD), total plasmatic antioxidant status (SAT) and urinary 8-isoprostanes will be performed at ICU admission, once a week, and at VAP occurrence.
Patients with VAP will be compared with those with no VAP
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients admitted to the ICU
- •Expected duration of mechanical ventilation > 48h
- •Signed informed consent
- •Social insurance
排除标准
- •Pregnancy or breast feeding
- •No informed consent
- •Hyperbaric oxygen treatment
- •Prisoners and patients under guardianship
结局指标
主要结局
VAP occurrence
时间窗: 28 days after ICU admission
hyperoxemia at ICU admission (PaO2 \>120 mmHg)
次要结局
- percentage of time spent with hyperoxemia during ICU stay, and the presence of acute lung injury(28 days after ICU admission)
- percentage of time spent with hyperoxemia during ICU stay(28 days after ICU admission)
- relationship between hyperoxemia at ICU admission and the presence of acute lung injury (ALI)(28 days after ICU admission)
研究者
研究点 (1)
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