Myocardial Fibrosis and Changes of Myocardial Function Related to Aging
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 74
- 试验地点
- 1
- 主要终点
- Regional myocardial strain
研究概览
简要总结
In normal ageing, the impact of myocardial fibrosis on myocardial function is unclear as diastolic function is reported to change according to age. The objective is to explore the relationship between myocardial function changes, with local (T1 and diffusion) fibrosis measures with Magnetic Resonance Imaging (MRI) as well as global measures of fibrosis (skin auto-fluorescence and collagen blood-biomarkers).
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •physical activity ≤ 3 x(30') per week
- •no history of smoking, diabetes, myocardial infarction, heart failure, hypertension (<140 or <90 mmHg) and no anti-hypertensive or cardiovascular-related medications
- •no familial history of early myocardial ischemia
- •body mass index (BMI) <30kg/m2
- •normal routine lipid blood analysis
- •glycemia <1.26g/l
- •normal electrocardiogram (ECG)
排除标准
- •arrhythmia
- •hepatic insufficiency
- •pregnancy
- •claustrophobia
- •MRI contrast allergy,
- •general contraindications to MRI such as pacemaker, etc.
研究组 & 干预措施
Healthy volunteers
Sedentary healthy subjects will be recruited in this study. MRI, skin auto-fluorescence measures and blood sampling will be performed
干预措施: Blood sampling (Biological)
Healthy volunteers
Sedentary healthy subjects will be recruited in this study. MRI, skin auto-fluorescence measures and blood sampling will be performed
干预措施: MRI (Device)
Healthy volunteers
Sedentary healthy subjects will be recruited in this study. MRI, skin auto-fluorescence measures and blood sampling will be performed
干预措施: Skin auto-fluorescence (Biological)
结局指标
主要结局
Regional myocardial strain
时间窗: The day of MRI
Segmental measures of systolic and diastolic strains with magnetic resonance imaging (MRI)
次要结局
- MRI T1 value(The day of MRI, 15 minutes after gadolinium injection)
- Apparent Diffusion Coefficient (ADC) with MRI(The day of MRI)
- Blood amino-terminal propeptide of procollagen type III (PIIINP) rate(The day of MRI)
- Blood carboxy-terminal propeptide of procollagen type I (PICP) rate(The day of MRI)
- Advanced Glycation End-products (AGE) rate(The day of MRI)
- MRI T1 value(The day of MRI, before gadolinium injection)