A Randomized, Multicenter, Double-Blind, Double-Dummy Study Comparing the Efficacy and Tolerability of Once Daily Celebrex (Celecoxib) and Naproxen 500 mg Twice Daily in the 6-month Treatment of Subjects With Osteoarthritis of the Knee

简要总结

主要结局

次要结局

• Number of health care professional contacts(Throughout study)
• Number of hospitalizations, emergency room visits, and procedures(Throughout study)
• Change in WOMAC Subscales from baseline(Month 6)
• Response in VAS(Month 6)
• Adverse events(Throughout study)
• Change in GI Distress Scale from time of discontinuation of study drug(Month 6)
• Patient's and Physician's Satisfaction with Current Arthritis Therapy(Month 6)
• Change in WOMAC Total Score from baseline(Month 6)
• Change in Gastrointestinal (GI) Distress Scale from Week 1(Month 6)
• Change in Work Limitation Questionnaire scale scores from baseline(Month 6)
• Response in each WOMAC Subscale(Month 6)
• Vital signs(Month 6)
• Change in visual analog scale (VAS) from baseline(Month 6)
• Change in Medical Outcome Study sleep scale from baseline(Month 6)
• Change in Patient's and Physician's Global Assessment of Pain from baseline(Month 6)
• Laboratory tests(Month 6)
• Receipt of prescription or over-the-counter gastroprotective agents or pain medications (off study drug)(Throughout study)
• Physical examination(Month 6)