NCT07642544尚未招募不适用
Effects of Different Secukinumab Maintenance Regimens on Long-Term Outcomes in Patients With Psoriasis: A Single-Center Real-World Cross-Sectional Retrospective Study
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School1 个研究点 分布在 1 个国家目标入组 120 人开始时间: 2026年6月1日最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 120
- 试验地点
- 1
研究概览
简要总结
To evaluate the long-term efficacy of two maintenance treatment patterns of secukinumab-the standard maintenance group and the non-standard maintenance group-by assessing the median time to onset and incidence of secondary failure, as well as the time to regain response after dose escalation of secukinumab (including re-initiation of intensive dosing or shortening of the injection interval) in patients who experienced secondary failure.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥ 18 years, with a clinical diagnosis of moderate-to-severe plaque psoriasis.
- •Initiated secukinumab treatment at our center between January 2020 and December 2025, and completed the standard 5-week induction period.
- •Achieved PASI 75 response at the end of the induction period.
- •Had a clearly defined maintenance treatment pattern (standard or non-standard), with complete treatment records and regular efficacy assessments.
- •Complete electronic medical record data available for extraction.
排除标准
- •Failure to complete the induction period, or failure to achieve PASI 75 response by the end of the induction period.
- •Irregular maintenance treatment pattern, or substantial missing data.
- •Use of other targeted biologic agents or small molecule drugs during the maintenance period.
- •Permanent discontinuation of treatment for non-efficacy reasons, such as pregnancy, severe infection, or malignancy.
- •Participation in other interventional clinical trials that may confound efficacy assessment.
研究者
taoyue
MD
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
研究点 (1)
Loading locations...
相似试验
尚未招募
不适用
A Real-world Study of Patients With Hidradenitis Suppurativa and High Cardiovascular Risk or Established Coronary Plaque Treated With SecukinumabHidradenitis SuppurativaNCT07454889Novartis Pharmaceuticals34
已完成
3 期
Study of efficacy and safety of secukinumab in participants with moderate-severe rotator cuff tendinopathy2022-502068-19-00Novartis Pharma AG81
尚未招募
Unknown
A clinical trial to study the efficacy of two drugs ,secukinumab and adalimumab in the treatment of hidradenitis suppurativaCTRI/2025/08/093223military hospital jaipur40
招募中
2 期
Identifying Effective and Cost-Conscious Maintenance Daratumumab DosingMultiple MyelomaNCT07485647Eden Biltibo50
招募中
3 期
A clinical study of sacituzumab tirumotecan in people with ovarian cancer (MK-2870-022)2023-508015-23-00Merck Sharp & Dohme LLC5