Neurological Outcome After Mild Induced Hypothermia (MIH) After Restoration of Spontaneous Circulation
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- Neurological outcome after 6 month after MIH, Quality of life-survey
研究概览
简要总结
Sudden cardiac arrest (SCA) remains one of the major leading causes of death. Cognitive deficits are common in survivors of SCA. Postresuscitative mild induced hypothermia (MIH) lowers mortality and reduces neurologic damage after cardiac arrest. The investigators evaluated the long term neurological outcome after mild hypothermia after restoration of spontaneous circulation.
详细描述
Consecutive patients with restoration of spontaneous circulation (ROSC) after resuscitation due to out-of-hospital SCA, admitted to our intensive care unit, underwent MIH. Hypothermia was induced by infusion of cold saline and whole-body-cooling methods (electronic randomization: invasive Coolgard or non-invasive ArcticSun). The core body temperature was operated at 32 to 34 °C over a period of 24 hours followed by active rewarming. Neurological status was evaluated at hospital discharge and 6 months after discharge using the Pittsburgh Cerebral Performance Category (CPC).
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •survived cardiac arrest
- •voluntary consent
排除标准
- •no voluntary consent
结局指标
主要结局
Neurological outcome after 6 month after MIH, Quality of life-survey
时间窗: 6 Month
Neurological outcome after 6 month after MIH measured by questionnaire.
次要结局
- Managing daily activities(6 Month)
- Neurological Outcome in consideration of the practice of the treating instances.(6 month)
- Neurological outcome depending of the beginning of MIH(6 month)
- Surviving after hospitalization(6 Month)