Prognostic Value of Eastern Cooperative Oncology Group Performance Status and American Society of Anesthesiologists Score in Patients Undergoing Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 2,515
- 主要终点
- Overall survival
研究概览
简要总结
Aim: to comprehensively evaluate the prognostic value of preoperative ECOG-PS scores and ASA scores in patients undergoing radical nephroureterectomy (RNU) for upper tract urothelial carcinoma.
Methods: multicentered cohort study
详细描述
Background:
The Eastern Cooperative Oncology Group (ECOG) performance status (PS) score and the American Society of Anesthesiologists (ASA) score are essential tools for the assessment of patients with various malignancies. However, doubts have arisen regarding their prognostic utility due to conflicting findings in limited studies. This study aims to comprehensively evaluate the prognostic value of preoperative ECOG-PS scores and ASA scores in patients undergoing radical nephroureterectomy (RNU) for upper tract urothelial carcinoma.
Materials and Methods
This multicentered cohort study enrolled patients who underwent RNU with curative intentat sixteen institutes in Taiwan from 1988 to 2023. Univariable and multivariable regression analyses were used to determine the impact of ECOG-PS scores and ASA scores on survival outcomes and postoperative complications. Patients were categorized based on ECOG-PS scores (0-1 vs. 2-4) and ASA scores (1-2 vs.3-4) according to prior literature.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All patients received UTUC surgery and follow-up in sixteen institutions across Taiwan
排除标准
- •Treatment not aimed at curative intent
- •Incomplete data
结局指标
主要结局
Overall survival
时间窗: 1988 to 2023
in days
Disease-free survival
时间窗: 1988 to 2023
in days
Bladder recurrence-free survival
时间窗: 1988 to 2023
in days
Cancer-specific survival
时间窗: 1988 to 2023
in days
次要结局
- Number of patients with postoperative renal failure(1988 to 2023)
- Number of patients with major postoperative complication(1988 to 2023)
研究者
Hsin-Chih Yeh
Principal investigator
Kaohsiung Medical University