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临床试验/NCT07832955
NCT07832955尚未招募不适用

Response of Muscle Mechanical Properties to Early Multi-angles Isometric Exercises in Acute Burn Patients

Cairo University0 个研究点目标入组 40 人开始时间: 2026年10月1日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
尚未招募
入组人数
40
主要终点
muscle dynamic stiffness

研究概览

简要总结

This study will be conducted to investigate the effect of early multi-angle isometric exercise on muscle properties in post-burn patients.

详细描述

A burn injury represents the fourth most common type of trauma globally, though it is associated with the most devastating consequences Severe burn injuries, encompassing ≥20% of the total body surface area (TBSA) in adults, present a unique challenge compared with other forms of trauma given the magnitude and persistence of systemic dysregulation.Burns can occur when the skin is exposed to heat sources, such as flames, flash burns, hot objects, grease, scald, chemicals, and electricity Burn injuries are highly variable, as is their severity. The patient's comorbidities can influence the burn's clinical outcome. Additionally, morbidity and mortality tend to increase as the surface area of the burn increases .Isometric exercise is a static form of exercise in which a muscle contracts and produces force without an appreciable change in the length of the muscle and without visible joint motion. Although there is no mechanical work done (force × distance), a measurable amount of tension and force output are produced by the muscle. Sources of resistance for isometric exercise include holding against a force applied manually, holding a weight in a particular position, maintaining a position against the resistance of body weight, or pushing or pulling an immovable object.Although post-burn muscle wasting is widely recognized, it is not consistently targeted as a primary rehabilitation outcome during the acute phase of care. Furthermore, there is a lack of randomized controlled trials examining the effects of early Multi- angle isometric exercise on objective measures of muscle mechanical properties in acute burn patients using sensitive technology like the MyotonPRO.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
Single (Outcomes Assessor)

盲法说明

opaque sealed envelope

入排标准

年龄范围
20 Years 至 40 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • Male and female patients aged 20 to 40 years
  • Patients diagnosed with acute burns.
  • Total Body Surface Area (TBSA) ranging from 15% to 30%, 2nd degree burn patients.
  • Medically stable patients.
  • Patients within the first 4 weeks post-burn (acute stage).
  • Burns affecting lower limb muscles (Quadriceps, Hamstring , and calf muscles ) .

排除标准

  • Patients with third-degree burns requiring immediate surgical grafting at the assessment site.
  • Patients with associated fractures or neurological disorders.
  • Patients with severe cardiopulmonary instability.
  • Patients under mechanical ventilation.
  • Patients with systemic diseases affecting muscle properties (e.g., neuromuscular disorders).

研究组 & 干预措施

isometric exercise program

Experimental

20 patients will receive early Multi-angle isometric exercise program in addition to conventional physical therapy 3 times per week for 3 weeks.

干预措施: isometric exercise program (Other)

isometric exercise program

Experimental

20 patients will receive early Multi-angle isometric exercise program in addition to conventional physical therapy 3 times per week for 3 weeks.

干预措施: conventional physical therapy (Other)

conventional physical therapy

Active Comparator

20 patients will receive conventional physical therapy 3 times per week for 3 weeks.

干预措施: conventional physical therapy (Other)

结局指标

主要结局

muscle dynamic stiffness

时间窗: up to 3 weeks

The MyotonPro (Myoton AS Tallinn, Estonia) device will be used to assess muscle dynamic stiffness. it introduces an innovative and non-invasive approach for comprehensively characterizing the biomechanical and viscoelastic properties of muscles.The device is applied under constant preload (0.18 N) to pre-compress subcutaneous tissues, and it exerts a brief (15 milliseconds) mechanical tap at a pre-determined force (0.4 Newtons), followed by quick release, causing damped oscillations that are recorded by the testing probe. This device is portable, inexpensive, easy to use, and convenient for re-cording the biomechanical and viscoelastic stiffness of myofascial tissues relatively quickly.A higher dynamic stiffness indicates greater resistance to force application.

次要结局

  • lower limb disability(up to 3 weeks)
  • oscillatory frequency(up to 3 weeks)
  • muscle elasticity(up to 3 weeks)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Vivian Essam Sadek Halim

principle investigator : vivian essam sadek

Cairo University

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