Cognitive Training in Patients With Mild Cognitive Impairment Using fMRI.
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- Changes in functional magnetic resonance imaging (fMRI)
研究概览
简要总结
The current project aims to investigate the trajectories of the visual imaging cognitive training (CT) and alphabet search training using fMRI in patients with amnestic mild cognitive impairment (MCI) and healthy elderly controls (HE). MCI patients will be grouped according to biomarkers (PET PIB).
详细描述
We will include 40 subjects with amnestic mild cognitive impairment (MCI) multiple domain clinical diagnostic, over 60 years old, recruited through the outpatient clinic of University of Sao Paulo General Hospital. We will also include 20 healthy subjects, over 60 years old, recruited in the community. All the participants will be evaluated by neurologists specialized in cognitive neurology and subjected to a neuropsychological assessment. The 40 participants with MCI and 20 healthy subjects will receive 6 sessions of visual imaging training. After this first study, they will receive cognitive training with alphabet search training. This will be a longitudinal study. MCI patients will be grouped according to biomarkers (PET PIB).
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None (Outcomes Assessor)
入排标准
- 年龄范围
- 60 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Portuguese as native and preferred language; A minimum of 4 years of education; MRI-compatible; Right-handed individuals; Normal corrected vision and hearing; Estimated intelligence average or above (≥ 80 IQ);
排除标准
- •History of neurological disorder, severe mental illness; Current untreated alcohol or substance abuse; Medical conditions that compromise in any way the central nervous system; Presence of visual impairment and / or hearing to preclude cognitive testing; Presence of contraindications to MRI exam; Findings in structural MRI that can interfere with the results of the study
研究组 & 干预措施
Visual Imaging Training
Participants will receive visual imaging training to facilitate learning of written information.
Intervention: Visual Imaging Training in individual sessions
干预措施: Memory Training (Behavioral)
Psychoeducation
Participants will receive information about memory functioning and aging.
Intervention: behavioral: Psychoeducation in individual sessions
干预措施: Psychoeducation (Behavioral)
Alphabet Search
Participants will receive alphabet search training.
Intervention: Alphabet Search in individual sessions
干预措施: Alphabet search (Behavioral)
结局指标
主要结局
Changes in functional magnetic resonance imaging (fMRI)
时间窗: Baseline and after 4 weeks of intervention fMRI correlates of behavioral performance
fMRI correlates of behavioral performance
Changes in memory and language measures
时间窗: Baseline and after 4 weeks of intervention - generalization
Improvement in Logical Memory Test I and II results and naming tests
Results from task performance in functional magnetic resonance imaging (fMRI)
时间窗: Baseline, after CT, and 12 months later
fMRI behavioral performance
次要结局
- Changes in perception of memory performance(Baseline, within four weeks after intervention)
- Changes in cognitive measures and brain activation(Baseline, after CT e 12 months follow-up)
研究者
Eliane Mioto
Prof. Dr Eliane C Miotto
São Paulo State University