Herd Immunity Study SARS-CoV-2-CZ-Preval
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 27,000
- 试验地点
- 1
- 主要终点
- Estimation of the actual prevalence of SARS-CoV-2 positive persons in the Czech Republic.
研究概览
简要总结
The aim of the SARS-CoV-2-CZ-Preval study is to quantify the prevalence of individuals with a history of SARS-CoV-2 coronavirus infection in the Czech population, except for those diagnosed with COVID-19 by methods based on direct detection of SARS-CoV- 2, including individuals with a subclinical course of the disease.
详细描述
COVID-19 is caused by a new type of coronavirus called SARS-CoV-2. It is a highly infectious disease, manifested mainly by fever, respiratory problems, muscle pain, and fatigue. However, despite the publication of hundreds of papers in the literature, fundamental information about the spread and course of the disease is still lacking in COVID-19. One of such key pieces of information is the prevalence of asymptomatic individuals with SARS-CoV-2 infection, which has a significant effect on the dynamics of the spread of COVID-19 in the Czech Republic and within individual regions and localities.
The SARS-CoV-2-CZ-Preval study is aiming at quantification of the prevalence of individuals with a history of SARS-CoV-2 coronavirus infection in the Czech population, except for those diagnosed with COVID-19 by methods based on direct detection of SARS-CoV- 2, including individuals with a subclinical course of the disease.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 8 Years 至 89 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •signed Informed Consent
- •residing in The Czech Republic
- •demographic criteria: (i) persons aged 8-17 (specific children's cohort), (ii) persons aged 18-89
- •clinical criteria: (i) without acute health problems (ii) without a confirmed diagnosis of COVID-19
- •geographic criteria: according to a particular cohort definition
排除标准
- 未提供
结局指标
主要结局
Estimation of the actual prevalence of SARS-CoV-2 positive persons in the Czech Republic.
时间窗: May 2020
Statistically, the primary objective is formulated as an estimate of the cumulative prevalence of SARS-CoV-2 positive individuals in geographically defined subpopulations of the Czech Republic with declared reliability of +/- 2%. For this primary objective, the required sample size in individual geographical cohorts is calculated. The positivity of SARS-CoV-2 individuals who have not been diagnosed with COVID-19 by a standard route of the detection will be assessed by the presence of specific IgM or IgG antibodies in the blood (antibody tests).
次要结局
- Estimation of the proportion of persons suitable for the donation of convalescent plasma(May 2020)
- Estimation of the proportion of people with a subclinical course of the disease(May 2020)
- Estimation of the cumulative prevalence of the disease and the proportion of people with a subclinical course differences between subcohorts according to demographic, social and clinically relevant stratifications.(May 2020)