A Major Determinant Focused on the ECG or Echocardiogram for Pacing-induced Cardiomyopathy (PICM) and Its Clinical Outcome (PICM Syndrome) : Prospective, Multi-center, Observational Cohort Study.
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 1,000
- 试验地点
- 3
- 主要终点
- Heart failure diagnosis and treatment
研究概览
简要总结
Chronic right ventricular pacing has a deleterious effect on left ventricular (LV) function, namely pacing-induced cardiomyopathy (PICM). Several parametes make difference of effect on the occurrence of PICM and its subsequent clinical outcomes. In particular, recognition of a major determinant focused on the ECG or echocardiographic parameters including strain or genetic factor for occurrence of PICM may lead to better identification of patients at high risk. Investigators prospectively enroll a participant with documented high risk of PICM and clinically follow-up to idenify clinical impact of PICM (PICM syndrome) over a long period of time.
详细描述
Investigators investigate a major determinant focused on the ECG or echocardiogram or genetic factor to predict the PICM after implantation of pacemaker. Not only QRS duration and mechanical strain but also genetic factor could be also investigated to predict the occurrence of PICM before diagnosis fo PICM
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •mandatory (1 and 2) and optional (3 or 4)
- •Willng to participate in the study and able to sign informed consent
- •Undertaken ECG and echocardiogram including strain before and after device implantation
排除标准
- •Less than 18 years of age
- •Being pregnant or plan to become pregnant
- •Advanced heart failure waiting in heart transplantation
- •Have a life expectancy of less than 1 year
结局指标
主要结局
Heart failure diagnosis and treatment
时间窗: 5 years
Occurrence of heart failure symptom, diagnosis and treatment
次要结局
- Atrial and Ventricular arrhythmia diagnosis, heart failure admisssion and all-caused mortality(5 years)
研究者
Ki-Woon Kang, MD
Professor
Chung-Ang University Hosptial, Chung-Ang University College of Medicine
