NCT06285513尚未招募不适用
Metabolic Remodeling Assessment During Severe Cardiovascular Dysfunction in Shock
University Hospital, Rouen1 个研究点 分布在 1 个国家目标入组 50 人开始时间: 2024年9月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Evaluation of the prognostic capacity of the initial metabolomic profile of patients in shock
研究概览
简要总结
The aim of the study is to increase our knowledge of energy dysfunction in the cardiovascular dysfunction observed during shock states by analysing the omics molecules involved.
详细描述
To do this, the investigators chose to carry out an in-depth study of the different metabolic pathways, using metabolomic analysis of plasma, targeting the cardiovascular metabolism of patients admitted to intensive care for septic and non-septic shocks.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient aged between 18 and
- •Patient admitted to intensive care for shock treated with a vasoactive or inotropic amine (adrenaline, dobutamine or noradrenaline).Patient undergoing invasive mechanical ventilation for less than 24 hours (or admitted to intensive care for less than 24 hours if the patient arrived intubated) and for a foreseeable duration of ventilation of at least 48 hours.
- •Patient, or relative if the patient is not competent, who has read and understood the information letter and does not object to participation in the research, or emergency procedure in the absence of a relative.
- •Urine or blood pregnancy test if a sample is taken as part of routine negative care (if woman of childbearing age).
排除标准
- •Moribund patient (death expected within < 24 hours) and/or decision to limit or stop treatment on admission to intensive care.
- •Pregnant, parturient or breast-feeding woman.
- •Patient not suitable for enteral calorie intake. Patient with a history of: advanced chronic renal failure ; advanced chronic liver failure.
- •Incapacitated patient of full age (under guardianship, curatorship) or deprived of liberty by court order.
- •Patient already taking part in an interventional study.
结局指标
主要结局
Evaluation of the prognostic capacity of the initial metabolomic profile of patients in shock
时间窗: Day 3
Correlation between plasma concentrations of metabolites at inclusion and delta of SOFA score (SOFA Day 1 - SOFA Day 3) with adjustment for SOFA at Day 1
次要结局
未报告次要终点
研究者
研究点 (1)
Loading locations...
相似试验
招募中
不适用
Metabolic Characterization of Patients With Dilated CardiomyopathyDCM - Dilated CardiomyopathyHeart FailureNCT05284682Göteborg University90
已完成
不适用
Study of the Cardiovascular Vitamin, CardioLifeCardiovascular DiseaseNCT02088307University of Utah21
Unknown
4 期
Cardiac Metabolic Modulator Treatment for Improvement of Diastolic Function in Patients With Coronary Heart DiseaseDiastolic DysfunctionCoronary Heart DiseaseNCT03887013China National Center for Cardiovascular Diseases226
已完成
不适用
UTSW HP [13-C] Pyruvate Injection in HCMDilated CardiomyopathyDuchenne Muscular DystrophyBecker Muscular DystrophyNCT03057002University of Texas Southwestern Medical Center7
撤回
早期 1 期
Understanding the Metabolic and Functional Derangement of Primary Mitral Regurgitation: a Feasibility Study Using Carbon 11(C-11) Acetate Cardiac Positron Emission Tomography Magnetic Resonance Imaging (PET-MRI)Mitral Valve RegurgitationNCT04795856University of Alabama at Birmingham12