跳至主要内容
临床试验/NCT06942845
NCT06942845进行中(未招募)不适用

Exploration of Risk Factors for Postoperative Cerebral Infarction in Lung Cancer Patients: a Retrospective Single-centre Study

Xinghua Cheng1 个研究点 分布在 1 个国家目标入组 300 人开始时间: 2025年4月1日最近更新:
适应症

试验速览

阶段
不适用
状态
进行中(未招募)
发起方
入组人数
300
试验地点
1
主要终点
Analysing independent risk factors for cerebral infarction after pneumonectomy

研究概览

简要总结

Lung cancer remains the world's leading cancer in terms of morbidity and mortality, with more than 20 million new cases and 9.7 million deaths annually. Despite improvements in surgical techniques and medical care, the number of elderly people undergoing surgery is gradually increasing, so there are an increasing number of complications following lung resection. Postoperative cerebral infarction is a relatively rare but devastating complication that places a heavy burden on patients and families. The incidence of postoperative cerebral infarction in patients after thoracic surgery has been reported to be 0.6-1.1%. There is a risk of postoperative cerebral infarction after lung cancer surgery, and the results of a few studies have shown that postoperative cerebral infarction is related to old age, male, hypertension, hyperlipidemia, and lobectomy factors, but the pathogenesis of the occurrence of cerebral infarction has not been clearly proved for the time being, and so these risk factors cannot be taken as the direct cause of cerebral infarction. Therefore, we need to further explore the factors leading to cerebral infarction after lung cancer surgery. If we can further prove that some of the risk factors are related to the causes of cerebral infarction after lung cancer surgery, we can make corresponding strategies in the perioperative period to improve the safety of surgery and reduce the incidence of cerebral infarction in the postoperative period.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Retrospective

入排标准

性别
All
接受健康志愿者
否

入选标准

  • •Postoperative cerebral infarction

排除标准

  • •No postoperative infarction

结局指标

主要结局

Analysing independent risk factors for cerebral infarction after pneumonectomy

时间窗: 5min

Clinical trial data were entered into Excel for recording information and subsequently converted to SPSS for statistical analysis. Descriptive statistics of the named data were expressed as absolute numbers and percentages according to each patient. Clinical characteristics of patients who developed cerebral infarction after surgery were retrospectively compared with those of patients who underwent pneumonectomy without cerebral infarction. Continuous data were expressed as median and interquartile range, and categorical data were expressed as frequencies and percentages. Independent risk factors for developing cerebral infarction after pneumonectomy were analysed using univariate and multivariate logistic regression.

次要结局

未报告次要终点

研究者

发起方
Xinghua Cheng
申办方类型
Other
责任方
Sponsor Investigator
主要研究者

Xinghua Cheng

deputy chief physician

Shanghai Chest Hospital

研究点 (1)

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