Transcranial Direct Current Stimulation as an Intervention in Tobacco Use Disorder: Effects on Consumption and Craving
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 44
- 试验地点
- 1
- 主要终点
- Reduced number of cigarettes smoked
研究概览
简要总结
This study aims to detect how transcranial direct current stimulation (tDCS) affects smokers' inhibitory control, craving and consumption of tobacco goods.
详细描述
Participating smokers are to receive anodal transcranial direct current stimulation of the right dorsolateral prefrontal cortex (rDLPFC) for 20 minutes on five consecutive days. Neuropsychological tests on inhibitory control and interviews on smoking habits and craving will be applied before and after the first stimulation as well as after the fifth stimulation.
After a follow-up period of three days, smoking behaviour will be assessed in a telephone interview.
Changes in inhibitory control and smoking behaviour will be compared between an active and a sham stimulation group.This way the effects of transcranial direct current stimulation on tobacco use disorder are to be clarified.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
盲法说明
Participants will be blinded as to their assigned study arm.
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •tobacco use disorder
- •normal or correctable eyesight
- •sufficient ability to communicate with the investigators, to answer questions in oral and written form
- •fully informed consent
- •written informed consent
排除标准
- •withdrawal of the declaration of consent
- •exclusion criteria for tDCS (metal implants in the head, acute eczema, known epilepsy)
- •severe internal, neurological or psychiatric comorbidity
- •pharmacotherapy with psychoactive substances within the last 14 days
- •axis-I disorder according to ICD-10 and DSM 5 (except tobacco use disorder)
- •positive urin drug screening (cannabis, amphetamine, opiates, benzodiazepines, cocaine)
- •pregnancy
结局指标
主要结局
Reduced number of cigarettes smoked
时间窗: First assessment on Day 1, second on Day 8
Smoking habits will be assessed via interview at the beginning of the study and after a follow-up period of three days. Number of cigarettes smoked will be compared longitudinally and between groups.
次要结局
- Reduced Carving(First assessment on Day 1, second on Day 5, third on Day 8)
- Increased inhibitory control(First and second testing on Day 1, third testing on Day 5)