NCT07601464招募中不适用
Evaluation of Tissue and Circulating microRNA Profiles in Patients With Hepatocellular Carcinoma Subjected to Thermal Ablation
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 150
- 试验地点
- 1
研究概览
简要总结
The main objectives of this research project concern the identification of microRNAs circulating and of serum metabolites predictive of treatment response in patients with early stage hepatocellular carcinoma undergoing locoregional treatment with thermoablation.
In addition, the molecular mechanisms involved in reprogramming will be identified metabolic via bioinformatics analysis and pretreatment liver biopsy analysis and analysis of screening on patient-derived primary lines for personalized therapy.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 64 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of hepatocarcinoma confirmed by radiology (LIRADS criteria/triphasic diagnostics) or by biopsy.
- •Indication for thermoablation treatment (for radiofrequency) based on the judgment of the hepatologist/surgeon.
- •Informed consent signed by the patient.
排除标准
- •Presence of metastatic liver lesions of other origins.
- •History of liver transplant.
- •Severe, uncorrectable coagulopathy, contraindicating liver biopsy (where necessary) or ablative procedure.
- •Patient refusal to participate in the study or inability to obtain informed consent.
- •Pregnant women.
研究者
研究点 (1)
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