Persistence of Severe Pulmonary Artery Hypertension in Patients After vaLve replacemenT
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- Persistence of pulmonary hypertension after valve replacement for treatment of severe valve disease
研究概览
简要总结
Background: Persistent severe pulmonary hypertension (PH) after mechanical valve replacement is a frequent finding in patients with severe valve-diseases. The reasons to develop PH are multifactorial and the prevalence of severe PH significantly worsens the patients´ outcome.
Aims: (i) To define the prevalence of PH in patients after valve replacement and (ii) to identify factors predicting persistent PH.
Methods: All patients which underwent valve replacement at our institution between the years 2008 -2010 will be screened retrospectively. Those patients with pre- procedural proven PH by means of right-heart catheterization will receive prospective follow-up with echocardiography. Diagnosis of persistent PH will be confirmed with right heart catheterization.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Proven pulmonary hypertension before valve replacement and informed consent for data acquisition
排除标准
- •patients do not meet inclusion criteria
结局指标
主要结局
Persistence of pulmonary hypertension after valve replacement for treatment of severe valve disease
时间窗: > 6 months after valve therapy
次要结局
- MACCE, all cause mortality during FU(Within 24 months after valve therapy)