Studies of Activity of Brown Adipose Tissue With Positron Emission Tomography Using the Tracer 18F-deoxy Glucose in Patients With Type 1 Diabetes
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 11
- 试验地点
- 2
- 主要终点
- Activity of brown adipose tissue in correlation to exogenous insulin needs using the tracer 18F-deoxy glucose in positron emission tomography measurements
研究概览
简要总结
Brown adipose tissue has the capacity to consume large amounts of energy and has insulin-independent glucose uptake. The investigators have recently observed an inverse correlation between irisin levels and insulin needs of type 1 diabetes patients. Transplantation of brown adipose tissue to insulin-deficient rats normalized their blood glucose levels.
In this study 12 patients with long-standing type 1 diabetes (>10 years) and with variable exogenous insulin needs will be investigated for amount of brown adipose tissue with positron emission tomography using the tracer 18F-deoxy glucose.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients (18 years of age or more)
- •Type 1 diabetes diagnose for more than 10 years
排除标准
- •Ongoing pregnancy
- •Ongoing breast-feeding
- •P-creatinine <110 µmol/l
研究组 & 干预措施
Type 1 diabetes
Positron emission tomography with tracer 18F-deoxy glucose
干预措施: Positron emission tomography with tracer 18F-deoxy glucose (Radiation)
结局指标
主要结局
Activity of brown adipose tissue in correlation to exogenous insulin needs using the tracer 18F-deoxy glucose in positron emission tomography measurements
时间窗: Assessment performed after more than 10 years of diagnosed type 1 diabetes
次要结局
- Glucose uptake in muscle in correlation to exogenous insulin needs; assessment using the tracer 18F deoxy glucose in positron emission tomography measurements.(Assessment performed after more than 10 years of diagnosed type 1 diabetes)
研究者
Per-Ola Carlsson
Professor, Senior consultant
Uppsala University Hospital