The Effect of Liposome Vitamin C on the Absorption
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 11
- 试验地点
- 2
- 主要终点
- vitamin c detection
研究概览
简要总结
To evaluate the difference between vitamin C in the form of oral liposomes and general vitamin C in a fixed period of time in plasma and urine.
详细描述
we recruited 11 healthy subjects and adopted a cross-over test. the subjects need to take 3 tests during trail. After each test was completed, a washout period of 14 days was required before the next test start. The subjects were informed to consume one sachet vitamin C without liposome, liposomal process A vitamin C, or liposomal process B vitamin C (Double Nutri™) every test, and vitamin C concentration was measured at baseline (0 hours), 0.5, 1, 2, 3, 4, and 8 hours after taking test sample.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Adults between 20-60 years old,
- •No heart, liver, kidney, endocrine and major organic diseases
排除标准
- •Renal insufficiency and dialysis
- •Underweight (BMI≦17) or obese (BMI≧27),
- •Take chronic disease drugs,
- •Blood pressure systolic blood pressure ≧130 mmHg or diastolic blood pressure ≧85 mmHg,
- •Too high fasting blood glucose ≧ 100 mg/dL,
- •Triglyceride ≧ 150 mg/dL,Total cholesterol ≧ 200 mg/dL,
- •Have a history of vitamin C allergy,
- •People with mental illness,
- •Pregnant or breastfeeding women,
- •Kidney stones,
- •Long-term vitamin C supplements (at least 200 mg per day for more than one month)
结局指标
主要结局
vitamin c detection
时间窗: at 8 hours after taking test sample
vitamin c was assessed by Ascorbic Acid Colorimetric Assay Kit II
The change of Triglyceride
时间窗: at 8 hours after taking test sample
Venous blood was sampled to measure concentrations of Triglyceride
The change of aspartate aminotransferase
时间窗: at 8 hours after taking test sample
Venous blood was sampled to measure concentrations of aspartate aminotransferase
The change of body mass index (BMI)
时间窗: Time 0, 0.5, 1, 2, 3, 4, and 8 hours after taking test sample
BMI is a measurement of a person's leanness or corpulence based on their height and weight, and is intended to quantify tissue mass.The body mass index (BMI, kg/m\^2) and body mass (kg) were assessed by InBody770.
The change of alanine aminotransferase
时间窗: at 8 hours after taking test sample
Venous blood was sampled to measure concentrations of alanine aminotransferase
The change of creatine
时间窗: at 8 hours after taking test sample
Venous blood was sampled to measure concentrations of creatine
次要结局
未报告次要终点