Comparative Characteristics of Asthmatic Patients With and Without Nasal Polyposis: an Observational, Cross-sectional Study of the Quebec Heart and Lung Institute-Laval University Asthma Database.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 1,293
- 试验地点
- 1
- 主要终点
- Asthma severity
研究概览
简要总结
Asthma is often associated with various comorbidities that may influence its clinical expression. Among those, chronic rhinosinusitis with nasal polyposis (CRSwNP) is observed in 5% of cases. Asthmatic patients with CRSwNP appear to have more severe and poorly controlled asthma, as well as greater bronchial and systemic inflammation, especially those using inhaled corticosteroids as control medication. However, this remains to be validated. In the last decade, there has been interest labeled for phenotyping of asthma and CRSwNP. However, there is scarce data on the phenotype of asthma with CRSwNP.
This study aims to describe the phenotype of asthmatic patients with CRSwNP according to the clinical, physiological and inflammatory characteristics and whether there is a more severe phenotype related to the dose of inhaled corticosteroids and the percentage of induced sputum eosinophils.
详细描述
This study will compare the characteristics of asthmatic patients with CRSwNP with those without CRSwNP.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Aged 18 years and over
- •With a proven diagnosis of asthma as defined by one of the above criteria of current guidelines:
- •Forced expiratory volume in one second (FEV1) increase by at least 12% (and ≥200 ml) after administration of a bronchodilator
- •Current asthma symptoms and a methacholine provocative concentration inducing a 20% fall in FEV1 (PC20) <16 mg/ml
- •A respirologist's current diagnosis of asthma found in the patient's medical report
- •Non-smokers or smokers/ex-smokers defined as someone with a smoking history <10 pack-years
- •Stable asthma and asthma medication for at least 4 weeks before data analysis
- •Written informed consent obtained for inclusion in the database
- •Patients with CRSwNP
- •With a proven diagnosis of CRSwNP, based on endoscopy and defined as the presence of endoscopically visible bilateral polyps growing from the middle meatus with or without involvement of the nasal cavities
排除标准
- •Any respiratory disease apart from asthma and CRSwNP
- •Current or ex-smokers should not have a smoking history ≥10 pack-years before data analysis. Patients who administer nicotine in other forms (patches, chew tobacco, e-cigarette, etc.) will be excluded
- •Unstable asthma medication <4 weeks before index date
- •Asthma exacerbation (see definition below) <4 weeks before index date
- •Respiratory tract infection <4 weeks before index date
结局指标
主要结局
Asthma severity
时间窗: Baseline
Prevalence of asthmatic with CRSwNP in mild, moderate and severe asthma
次要结局
- Sputum inflammatory phenotype(Baseline)
研究者
Louis-Philippe Boulet
MD, FRCPC, FCCP, respirologist
Laval University