NCT00419445已完成1 期
A Double-Blind, Randomized, Proof-of-Concept Crossover Trial to Assess the Effects of GTS21 on Cognitive Function, Clinical Symptoms, and Adverse Events in Adults Diagnosed With Attention-Deficit Hyperactivity Disorder
CoMentis2 个研究点 分布在 1 个国家目标入组 37 人开始时间: 2007年2月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 37
- 试验地点
- 2
- 主要终点
- To Assess the Safety and Tolerability of GTS21 (25 mg Tid, 75 mg Tid, 150 mg Tid).
研究概览
简要总结
This study will be a randomized, double-blind, placebo-controlled crossover study to assess the effects of GTS21 (25 mg three times a day (tid), 75 mg tid, 150 mg tid) compared to placebo in non-smoking adults aged 18-55 with a diagnosis of ADHD, any subtype.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Male or female between the ages of 18-55, inclusive.
- •Diagnostic and Statistical Manual for the Classification of Mental Disorders, Fourth Edition (DSM-IV) criteria for ADHD, any subtype, based on a detailed psychiatric evaluation including the Conners' Adult ADHD Interview for DSM-IV (CAADID) and the Structured Clinical Interview for DSM-IV (SCID).
- •A minimum Total ADHD Symptoms Index score of 28 on the clinician administered CAARS.
- •A Clinical Global Impressions-Severity (CGI-S) score of ≥ 4 at Screening.
- •Normal or clinically insignificant ECG and clinical laboratory (e.g., liver enzymes, complete blood count, etc.) findings at Screening.
- •Intellectual function at age-appropriate levels, as deemed by the Investigator.
- •Supine systolic and diastolic blood pressure measurements < 140 and < 90, respectively, at Screening.
- •Written, signed and dated informed consent for the patient to participate in the study must have been given by the patient.
- •Females of child-bearing potential must have had a negative serum beta human chorionic gonadotropin (HCG) pregnancy test at Screening and be practicing double-barrier methods of contraception, if sexually active and for 30 days following administration of any study drug.
- •Male patients who were sexually active must have agreed to use a reliable form of contraception during the study and for 30 days following administration of any study drug.
- •Be fluent in English (speaking, writing and reading).
排除标准
- •Any current, controlled (requiring a prohibited medication) or uncontrolled, comorbid psychiatric diagnosis (except simple phobias), all major depressive disorders [dysthymia and mood disorder not otherwise specified (NOS) allowed unless medication required],and any severe comorbid Axis II disorders or severe Axis I disorders such as Post Traumatic Stress Disorder, bipolar illness, psychosis, obsessive-compulsive disorder, substance abuse disorder, or other symptomatic manifestations that, in the opinion of the Investigator, contraindicated treatment with GTS21 or confound efficacy or safety assessments.
- •Any condition or illness (including clinically significant abnormal laboratory values) which, in the opinion of the Investigator, represented an inappropriate risk to the patient and/or could confound the interpretation of the study.
- •Regular use of nicotine products (including 90 days before Screening), including smoking, transdermal patch, chewing tobacco, etc. (verified via salivary cotinine levels at Screening).
- •Current use of any prohibited medication or other medications, including herbal supplements, that have central nervous system (CNS) effects or affect cognitive performance, such as sedating antihistamines and decongestant sympathomimetics (bronchodilators were permitted).
- •Use of another investigational product or participation in a clinical study within 30 days prior to Screening.
- •Body Mass Index (BMI) >
- •Known or suspected allergy, hypersensitivity, or clinically significant intolerance to nicotine or nicotinic agonists.
- •Clinically important abnormality on urine drug screen (excluding the patient's current ADHD stimulant, if applicable) at Screening.
- •Pregnant or currently lactating.
- •Patients that had previously been enrolled into this study and subsequently withdrawn.
研究组 & 干预措施
GTS21 150 mg tid/Placebo 150 mg tid
Active Comparator
干预措施: GTS21/Placebo (Drug)
GTS21 25 mg tid/Placebo 25 mg tid
Active Comparator
干预措施: GTS21/Placebo (Drug)
GTS21 75 mg tid/Placebo 75 mg tid
Active Comparator
干预措施: GTS21/Placebo (Drug)
结局指标
主要结局
To Assess the Safety and Tolerability of GTS21 (25 mg Tid, 75 mg Tid, 150 mg Tid).
时间窗: Baseline to study completion
The proportion of subjects with Treatment Emergent Adverse Events.
次要结局
未报告次要终点
研究者
研究点 (2)
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