The Comparison of Bruch's Membrane Opening-minimum Rim Width and Retinal Nerve Fiber Layer Thickness and Their Combinational Index Using Artificial Neural Network
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 402
- 试验地点
- 1
- 主要终点
- Bruch's membrane opening - minimum rim width (BMO-MRW)
研究概览
简要总结
This study evaluates the relationship between BMO-MRW and RNFL thickness measured by OCT. SD-OCT exam will be performed to all patients in this study.
详细描述
spectral domain optical coherence tomography, SD-OCT, (Heidelberg Engineering, Heidelberg, Germany) is a widely used commercial device in ophthalmology field. For a long time, retinal nerve fiber layer (RNFL) thickness was measured with OCT to detect and follow up glaucoma patients. Bruch's membrane opening - minimum rim width (BMO-MRW) is relatively new parameter which measures the minimum distance between Bruch's membrane opening to internal limiting membrane (ILM). BMO-MRW,a new parameter, is known to have better diagnostic performance than RNFL thickness and recently, many researches has been performed on this new parameter. SD-OCT can measure RNFL thickness and BMO-MRW at the same time. The test procedure is not different from RNFL thickness measurement but only software implemented in OCT device calculates BMO-MRW as well as RNFL thickness. The investigators are going to compare these two parameters and find out the relationship between two parameters.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 19 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age > 18 years with a clear cornea and clear ocular media
- •BCVA ≥ 20/40
- •Refractive error within ± 6.0 diopters (D) of 0 and astigmatism ± 3.0 D of 0
排除标准
- •secondary glaucoma
- •corneal abnormalities
- •non-glaucomatous optic neuropathies
- •previous trauma
- •ocular surgery or laser treatment
- •any other eye disease except glaucoma.
结局指标
主要结局
Bruch's membrane opening - minimum rim width (BMO-MRW)
时间窗: 5~10 minutes
SD-OCT will be performed to the patients to measure BMO-MRW by trained glaucoma specialist.
次要结局
- Retinal nerve fiber layer (RNFL) thickness(5~10 minutes)
