Cortical Contributions to Frequency-Following Response Generation and Modulation; Post-Operative Outcomes
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- Predictability Effects of Cortical Resection on Frequency-Following Response Magnitude
研究概览
简要总结
The purpose of this study is to better understand cortical contributions of the human temporal lobe to the frequency-following response. Frequency-following responses (FFR) are electrophysiological recordings that reflect phase-locked activity of neural ensembles in the auditory pathway and are used as an indicator of the integrity of supra-threshold speech processing. FFR was first studied in subcortical areas, but recent consensus in the literature supports the notion that it is an integrated response between subcortical and cortical neural populations. The proposed study aims to deconstruct the role of the cortex in generating and modulating the FFR. The research team will build a novel computational model of FFR mechanisms and use EEG recordings from participants who have undergone resection of lesions in Heschl's gyrus to validate model predictions.
详细描述
The purpose of this study is to better understand the cortical contribution of the human temporal lobe to the generation and modulation of frequency-following responses (FFR).
The specific aims of this study is as follows:
- To build a novel computational model of cortical feedforward mechanisms involved in FFRs.
- To test model predictions of cortical removal in human participants who have undergone surgical resection of Heschl's gyrus lesions.
The hypothesis to be tested for the previously listed purposes and aims are as follows:
1. When cortical areas involved in generating and modulating the FFR, in this case Heschl's gyrus, are removed or inactivated, the FFR response will be attenuated.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 13 Years 至 25 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Individuals 13-25 years old
- •Undergoing medically necessary surgical resection of Heschl's gyrus lesion
- •Monolingual English speakers
- •Receptive and expressive language within normal limits
- •Normal or corrected-to-normal visual acuity
- •Normal hearing acuity in each ear (as determined during an audiometric assessment)
- •Nonverbal IQ within normal limits
- •No history of autism spectrum disorder or attention-deficit hyperactivity disorder
排除标准
- •Significant medical or neuropsychological impairment that would result in the patient being unable to participate in study activities
- •History of autism or ADHD
研究组 & 干预措施
Neurosurgical Patients
Patient participants with previously excised tissue within Heschl's gyrus (as dictated by clinical care)
干预措施: Speech sound stimulation (Behavioral)
结局指标
主要结局
Predictability Effects of Cortical Resection on Frequency-Following Response Magnitude
时间窗: During follow-up research sessions, at least 6-months post-sEEG
The predictability effects of cortical resection on frequency-following response magnitude will be measured via comparison of response magnitude measurements obtained in Outcome 3 and values predicted by a previously created computational model of frequency-following response constrained by data from neurotypical participants.
Frequency-Following Response Magnitude
时间窗: During sEEG-EEG recording sessions, up to 3 hours total
The frequency-following response magnitude will be measured by analyzing the time-domain averaged spectral peak of scalp-recorded FFRs.
Predictability Effects of Cortical Resection on Phase-Locking Limits of Frequency-Following Response
时间窗: During follow-up research sessions, at least 6-months post-sEEG
The predictability effects of cortical resection on phase-locking limits of the frequency-following response will be measured via comparison of phase-locking limits obtained in Outcome 3 and values predicted by a previously created computational model of frequency-following response constrained by data from neurotypical participants.
Cortical Phase-Locking Limits of Frequency-Following Response
时间窗: During sEEG-EEG recording sessions, up to 3 hours total
Phase-locking limits of FFRs will be measured by comparing phase coherence of stimulus waveforms and scalp-recorded FFRs. The phase-locking limit will be determined as a function of dependence on stimulus frequency.
Pitch Decoding Accuracy
时间窗: During sEEG-EEG recording sessions, up to 3 hours total
Pitch decoding accuracy will be measured as a stimulus-to-response correlation between stimulus pitch (in Hz) and scalp-recorded frequency-following responses (FFR). Hidden Markov models (HMMs) will be used to decode stimulus identity information from recorded FFRs.
Predictability Effects of Cortical Resection on Pitch Decoding Accuracy
时间窗: During follow-up research sessions, at least 6-months post-sEEG
The predictability effects of cortical resection on pitch decoding accuracy will be measured via comparison of decoding accuracies obtained in Outcome 1 and values predicted by a previously created computational model of frequency-following response constrained by data from neurotypical participants.
次要结局
未报告次要终点
研究者
Taylor Abel
Assistant Professor
University of Pittsburgh