ACTRN12623001226695招募中1 期
Does the rate of reduction in blood glucose impact the gastric counter-regulatory response during acute hypoglycaemia in adults with type 1 diabetes?
Central Adelaide Health Network0 个研究点目标入组 12 人开始时间: 2023年11月28日最近更新:
适应症
试验速览
- 阶段
- 1 期
- 状态
- 招募中
- 发起方
- 入组人数
- 12
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Diagnosis
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 18 Years 至 80 Years（—）
- 性别
- All
入选标准
- •Men and women with type 1 diabetes
- •Aged 18 years and over
- •HbA 1c lesser than or equal to 9.5 %
排除标准
- •History of type 2 diabetes
- •HbA 1c greater than 9.5 %
- •History of gastrointestinal disease, including known gastroparesis, peptic
- •ulcer disease, significant upper or lower gastrointestinal symptoms, or
- •previous gastrointestinal surgery (other than uncomplicated
- •appendicectomy or cholecystectomy) or a history of migraine or panic
- •Other significant illness, including epilepsy, cardiovascular or respiratory
- •Chronic Kidney Disease (CKD) 4-5 (eGFR less than 30) or if iron stores or liver function tests are outside the
- •following normal ranges:
- •- Haemoglobin 130 – 180 g/L (Males)
- •- Haemoglobin 115 – 155 g/L (Females)
- •- Ferritin less than 30 µg/L (Males)
- •- Ferritin less than 15µg/L(Females)
- •Requirement for medication known to influence gastrointestinal function,
- •(e.g. prokinetic drugs [metoclopramide, domperidone, erythromycin],
- •antiemetics [ondansetron], antidiarrhoeals [loperamide], H 2 receptor
- •antagonists [ranitidine], drugs with substantial anticholinergic effects
- •[amitriptyline, doxepin, dothiepin, mirtazapine, haloperidol,
- •chlorpromazine, risperidone, oxybutynin], opioids [morphine, oxycodone,
- •codeine], orlistat.
- •Evidence of drug or alcohol abuse, or consumption of more than 20 g
- •alcohol or 10 cigarettes on a daily basis.
- •Donation of blood within the previous 3 months
- •Participation in any other research studies within the previous 3 months
- •Previous exposure to radiation for research purposes in the preceding 12
- •Inability to give informed consent
- •Positive pregnancy status or lactating (breast-feeding) female
- •Vegetarian or vegan
研究者
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