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临床试验/NCT07206433
NCT07206433尚未招募不适用

Identification and Perceptions of Spoken Language Abilities After Transient Ischaemic Attack (TIA): An Exploratory, Longitudinal Study

Newcastle University1 个研究点 分布在 1 个国家目标入组 30 人开始时间: 2025年10月1日最近更新:

试验速览

阶段
不适用
状态
尚未招募
入组人数
30
试验地点
1
主要终点
Speech rate

研究概览

简要总结

Transient Ischaemic Attack (also known as TIA or 'mini-stroke') affects about 46,000 people in the UK each year. It is assumed that people recover fully within 24 hours. However, subtle problems with speaking, and confidence with their communication skills can be long-term. This project will be the first in depth exploration of speaking abilities after recent TIA where there seemed to be a full recovery.

The researchers will look for 90 volunteers for detailed testing. Thirty people who have had a TIA for the first time. For comparisons, the researchers will also include 60 volunteers without TIA (30 treated to prevent TIA and stroke; 30 who do not receive prevention treatments).

Aims and methods:

  1. To find out if TIA makes speaking difficult.

People will complete speaking tasks in a quiet place. For example, people will be asked to tell us about their weekend, what they think about climate change. 2. To find out if people are concerned about their speech and other thinking skills after TIA.

People will fill in questionnaires to help us look into these issues. 3. To find out if speaking abilities and people's own views of their communication change over time (about three months after the TIA).

Discovering new knowledge about spoken communication after a TIA diagnosis could change the course of TIA research and care across health professions (speech-language therapy, psychology, audiology, neurology). Future studies could use speaking tasks to scrutinise further the complexity of subtle communication problems after TIA and determine which individuals are likely to have these problems. The project will raise understanding of these issues, enabling affected individuals to seek professional support. Finally, it will also guide development of new TIA recommendations and treatments for these problems thus improving people's quality of life.

详细描述

Montreal Cognitive Assessment (MoCA; (Nasreddine et al., 2005): Assesses general cognitive function; reliable and valid; different versions for repeated assessment (e.g., sentence repetition "I only know that John is the one to help today"; You'll hear a list of numbers and I'd like you to repeat them in the order you heard them).

Everyday Memory Questionnaire (Sunderland et al., 1986): Self-reported measure of cognitive skills many of which are about communication, language and reading (Likert scale) (e.g., forgetting the names of friends or relatives or calling them by the wrong names; getting lost or turning in the wrong direction on a journey or walk you have often been on).

Data analyses

For aims 1 and 2, the methods of analysis for each of the outcome measures is detailed below and will be in conducted in R.

Descriptive statistics by subgroup (medians, range, inter-quartile range) will be generated for each outcome measure (speech-related [primary, secondary], Everyday Memory Questionnaire, Communication Confidence Rating Scale for Aphasia).

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Cross Sectional

入排标准

年龄范围
40 Years 至 85 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • People aged 40-85 with a diagnosis of a single carotid circulation TIA.

排除标准

  • Younger than 40 years or older than 85 years of age.
  • English as a secondary language.
  • Neurological conditions affecting cognitive function (e.g., Parkinson's disease, dementia, stroke).
  • Self-reported, pre-existing speech or cognitive problems, developmental or acquired.
  • Demonstrate noticeable difficulties carrying out project-related tasks.

结局指标

主要结局

Speech rate

时间窗: From enrollment

measured as number of words per minute

Mean length of sentence

时间窗: From enrollment

measured in number of words

Sentence complexity

时间窗: From enrollment

measured as number of complex sentences

Functional Memory Questionnaire

时间窗: From enrollment

Patient-reported measure of perceptions of memory, attention, language abilities; score range 0 to 140; higher scores mean a worse outcome

Communication Confidence Rating Scale for Aphasia

时间窗: From enrollment

Patient-reported measure of confidence of communication abilities; score range 0 to 600; higher scores mean worse outcome

次要结局

  • Filled pause rate(From enrollment)
  • Lexical richness(From enrollment)
  • Propositional idea density(From enrollment)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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